Mecamylamine
- Atc Codes:C02BB01
- CAS Codes:826-39-1#60-40-2
- PHARMGKB ID:826-39-1#60-40-2
Table of contents
- Chemistry
- Pharmacologic Category
- Mechanism of Action
- Therapeutic Use
- Unlabeled Use
- Contraindications
- Warnings and Precautions
- Adverse Reactions
- Toxicological Effects
- Genes that may be involved
- Drug Interactions
- Dosage
- Special Considerations
Brand Names
Drug combinations
Chemistry
Mecamylamine Hydrochloride: C~11~H~21~N HCl. Mw: 203.75. (1) Bicyclo[2.2.1]heptan-2-amine, N,2,3,3-tetramethyl-, hydrochloride; (2) N,2,3,3-Tetramethyl-2-norbornanamine hydrochloride. CAS-826-39-1; CAS-60-40-2 (mecamylamine).
Pharmacologic Category
Hypotensive Agents, Miscellaneous; Ganglionic Blocking Agent. (ATC-Code: C02BB01).
Mechanism of action
Inhibits acetylcholine at autonomic ganglia, causing decrease in blood pressure. Also blocks central nicotinic cholinergic receptors, which inhibits effects of nicotine and may suppress desire to smoke.
Therapeutic use
Treatment of moderately severe to severe hypertension and in uncomplicated malignant hypertension.
Pregnancy and lactiation implications
Unlabeled use
Tourette’s syndrome.
Contraindications
Coronary insufficiency, pyloric stenosis, glaucoma, uremia, recent MI.
Warnings and precautions
Use with caution in previous CNS abnormalities, in prostatic hyperplasia, bladder obstruction, or urethral stricture (might cause urinary retention), and in renal impairment. Do not discontinue abruptly.