Table of contents

  • Brand Names
  • Chemistry
  • Pharmacologic Category
  • Mechanism of Action
  • Therapeutic Use
  • Pregnancy and Lactation Implications
  • Contraindications
  • Warnings and Precautions
  • Adverse Reactions
  • Genes that may be involved
  • Drug Interactions
  • Dosage
  • Pharmacokinetics and Pharmacodynamics
  • Special Considerations

Brand Names

North America

Canada: HMS.

Drug combinations


Medrysone: C~22~H~32~O~3~. Mw: 344.49. (1) Pregn-4-ene-3,20-dione, 11-hydroxy-6-methyl-, (6α,11β)-; (2)11β-Hydroxy-6α-methylpregn-4-ene-3,20-dione. CAS-2668-66-8 (1965).

Pharmacologic Category

EENT Preparations; Anti-inflammatory Agents; Corticosteroids. Ophthalmic Corticosteroid. (ATC-Code: S01BA08).

Mechanism of action

Decreases inflammation by suppression of migration of polymorphonuclear leukocytes and reversal of increased capillary permeability.

Therapeutic use

Treatment of allergic conjunctivitis, vernal conjunctivitis, episcleritis, ophthalmic epinephrine sensitivity reaction.

Pregnancy and lactiation implications

Use with caution during pregnancy and lactation.

Unlabeled use


Hypersensitivity to medrysone or any component of the formulation. Fungal, viral, or untreated pus-forming bacterial ocular infections. Not for use in iritis and uveitis.

Warnings and precautions

Steroids might mask infection or enhance existing ocular infection. Possible secondary infections due to immunosuppression (with prolonged use). Prolonged use may result in glaucoma and injury to optic nerve. Visual defects in acuity and field of vision might also occur. Posterior subcapsular cataracts may form after long-term use. Use with caution in presence of glaucoma (steroids increase intraocular pressure). Perforation may occur with topical steroids in diseases which thin cornea or sclera. Steroid use may delay healing after cataract surgery.



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