Anaphylactoid reactions might occur (do not use in asthma, bronchospasm, rhinitis, or urticaria with NSAID or aspirin therapy). Platelet adhesion and aggregation may be decreased. Might prolong bleeding time. Anemia might occur. NSAIDs are associated with increased risk of adverse cardiovascular thrombotic events, including myocardial infarction, stroke, and new onset or worsening of pre-existing hypertension. NSAIDs may increase risk of gastrointestinal irritation, inflammation, ulceration, bleeding, and perforation (use caution with history of bleeding or ulcers, concurrent therapy with aspirin, anticoagulants and/or corticosteroids, smoking, use of alcohol, elderly or debilitated patients). NSAIDs might cause serious skin adverse events including exfoliative dermatitis, Stevens-Johnson syndrome, and toxic epidermal necrolysis. Do not administer in aspirin-sensitive asthma (severe bronchospasm might occur) and use caution in other forms of asthma. Use contraindicated for treatment of perioperative pain in setting of coronary artery bypass graft surgery. Use with caution in decreased hepatic function. The elderly are at increased risk for adverse effects (especially peptic ulceration, CNS effects, renal toxicity). Withhold prior to surgical or dental procedures. Use not recommended in pre-existing renal disease or substantial renal impairment.