Table of contents

  • Brand Names
  • Drug Combinations
  • Chemistry
  • Pharmacologic Category
  • Mechanism of Action
  • Therapeutic Use
  • Pregnancy and Lactation Implications
  • Contraindications
  • Warnings and Precautions
  • Adverse Reactions
  • Caution and personalized dose adjustment in patients with the following genotypes
  • Other genes that may be involved
  • Substrate of
  • Inhibits
  • Drug Interactions
  • Nutrition/Nutraceutical Interactions
  • Dosage
  • Pharmacokinetics and Pharmacodynamics
  • Special Considerations

Brand Names


Austria: Meloxicam, Metosan, Mobic, Movalis; Belgium: Docmeloxi, Meloxicam, Mobic; Bulgaria: Loximed, Melbek, Melox, Movalis, Movix, Noflamen, Recoxa; Cyprus: Loxim, Melgesic, Melorem, Mobic; Czech Republic: Antrend, Artrilom, Duplicam, Enaros, Melobax, Melocox, Melovis, Meloxicam, Meloxistad, Movalis, Movmaks, Noflamen, Recoxa; Denmark: Meloxicam; Estonia: Lormed, Melox, Meloxicam, Meloxistad, Mexolan, Movalis, Recoxa; Finland: Meloxicam, Mobic; France: Meloxicam, Mobic; Germany: Acticam, Animeloxan, Flexicam, Loxicom, Melox, Meloxicam, Metacam, Mobec, Mobic, Movalis, Movatec, Oximel, Rheumocam; Greece: Arsitec, Arthrox, Articam, Auroxicam, Brosiral, Doctinon, Examel, Farmelox, Flumidon, Iamaxicam, Iaten, Iconal, Infomel, Loxitan, Mecalox, Medoxicam, Melcam, Melice, Melocalm, Melock, Melocox, Melodim, Meloprol, Melorem, Melorilif, Melotec-Therapy, Melotop, Melox-Raldex, Meloxicam, Meloxil, Meloxitor, Melus, Meomel, Movalis, Movatec, Movaxin, Moxalid, Notpel, Parogal, Partial, Philipon, Rentilox, Reumotec, Reumotherm, Sanetron, Saniflam, Starmelox, Supercad, Transantor, Tropofin, Valoxin, Vexicam, Zametrixal, Zerelin; Hungary: Antrend, Borbin, Camelox, Melodyn, Melogen, Melox EP, Meloxan, Meloxicam, Meloxistad, Movalis, Movmax, Moxicam, Noflamen; Ireland: Areloger, Melcam, Meloxicam, Mobic, Mobicam, Mobiglan, Movox; Italy: Gixal, Leutrol, Meloxicam, Mobic; Latvia: Lormed, Melobax, Melox, Meloxicam, Meloxistad, Mexolan, Movalis, Noflamen, Normelox, Recoxa; Lithuania: Meloxicam; Luxembourg: Mobic; Malta: Melorem, Melox, Meloxicam, Mobic, Mobiglan; Netherlands: Meloxicam, Movicox; Poland: Aglan, Antrend, Aspicam, Celomix, Lormed, Melobax, Meloksam, Melokssia, Melotev, Meloxic, Meloxicam, MeloxiLek, Meloxistad, Movalis, Noflamen; Portugal: Meloxicam, Movalis; Romania: Antrend, Aspiflex, Celomix, Melartrin, Melox, Meloxicam, Movalis, Moxcipam, Noflamen, Recoxa, Valzer; Slovakia: Antrend, Celomix, Lormed, Melobax, Melodyn, Meloxan, Meloxicam, Meloxistad, Movalis, Noflamen, Recoxa; Slovenia: Celomix, Lormed, Meloksikam, Meloxan, Movalis; Spain: Aliviodol, Meloxicam, Movalis, Parocín; Sweden: Enaros, Meloxicam, Mobic; UK: Mobic.

North America

Canada: Meloxicam, Mobicox; USA: Meloxicam, Mobic.

Latin America

Argentina: Bronax, Dominadol, Flexidol, Flexium, Loxitenk, Melorac, Meloxicam, Mextran, Miolox, Mobic, Tenaron; Brazil: Bioflac, Dormelox, Inicox, Leutrol, Loxam, Loxiflan, Melotec, Meloxicam, Meloxigran, Meloxil, Mevamox, Movatec, Movoxicam; Mexico: Aflamid, Anpre, Auricam, Coxylan Ofteno, Dolocam, Exel, Flexiver, Flexol, Lexpram, Loxibach, Loxibest, Mavicam, Maxoflam, Meflen, Melarthyl, Melosteral, Meloxicam, Menflixil, Mobicox, Promotion, Rafitex, Reosan, Retoflam.


Japan: Meloxicam, Mobic.

Drug combinations

Meloxicam and Carisoprodol

Meloxicam and Diacerein

Meloxicam and Methocarbamol

Meloxicam, Cyanocobalamin (Vitamin B~12~), Pyridoxine (Vitamin B~6~), and Thiamine (Vitamin B~1~)


Meloxicam: C~14~H~13~N~3~O~4~S~2~. Mw: 351.40. 4-Hydroxy-2-methyl-N-(5-methyl-2-thiazolyl)-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide. CAS-71125-38-7 (1997).

Pharmacologic Category

Analgesics and Antipyretics; Other Nonsteroidal Anti-inflammatory Agents. (ATC-Code: M01AC06).

Mechanism of action

Reversibly inhibits cyclooxygenase-1 and 2 (COX-1/PTGS1 and COX-2/PTGS2) enzymes, which result in decreased formation of prostaglandin precursors. Has antipyretic, analgesic, and anti-inflammatory properties.

Therapeutic use

Relief of signs and symptoms of osteoarthritis, rheumatoid arthritis, and juvenile rheumatoid arthritis.

Pregnancy and lactiation implications

This drug should not be used in 3^rd^ trimester of pregnancy (might cause premature closure of ductus arteriosus). Use not recommended while breast-feeding.

Unlabeled use


Hypersensitivity (e.g. asthma, allergic-type reactions, urticaria) to meloxicam, aspirin, other NSAIDs, or any component of the formulation. Perioperative pain in setting of coronary artery bypass graft surgery.

Warnings and precautions

Anaphylactoid reactions might occur. Do not use in asthma, bronchospasm, rhinitis, or urticaria with NSAID or aspirin therapy. Platelet adhesion and aggregation may be decreased. Might prolong bleeding time. Anemia might occur. NSAIDs associated with increased risk of adverse cardiovascular thrombotic events, including myocardial infarction, stroke, and new onset or worsening of pre-existing hypertension. NSAIDs might increase risk of GI irritation, inflammation, ulceration, bleeding, and perforation. Use caution with history of bleeding or ulcers, concurrent therapy with aspirin, anticoagulants and/or corticosteroids, smoking, use of alcohol, elderly or debilitated patients. NSAIDs might cause serious skin adverse events including exfoliative dermatitis, Stevens-Johnson syndrome, and toxic epidermal necrolysis. Do not administer in aspirin-sensitive asthma (severe bronchospasm might occur), and use caution in other forms of asthma. Use contraindicated for treatment of perioperative pain in setting of CABG surgery. Use with caution in decreased hepatic function. NSAID use may compromise existing renal function. Patients with impaired renal function, dehydration, heart failure, liver dysfunction, those taking diuretics, and ACEIs, and the elderly are at greater risk of renal toxicity. Not recommended for use in advanced renal disease. Long-term NSAID use may result in renal papillary necrosis. The elderly are at increased risk for adverse effects (especially peptic ulceration, CNS effects, renal toxicity). Surgical/dental procedures: Withhold prior to surgical or dental procedures.



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