Mepenzolate
- Atc Codes:A03AB12
- CAS Codes:76-90-4#25990-43-6
- PHARMGKB ID:76-90-4#25990-43-6
Table of contents
- Brand Names
- Chemistry
- Pharmacologic Category
- Mechanism of Action
- Therapeutic Use
- Pregnancy and Lactation Implications
- Contraindications
- Warnings and Precautions
- Adverse Reactions
- Genes that may be involved
- Drug Interactions
- Dosage
- Pharmacokinetics and Pharmacodynamics
- Special Considerations
Brand Names
North America
USA: Cantil.
Asia
Japan: Atenecolin, Eftoron, Trancolon.
Drug combinations
Chemistry
Mepenzolate Bromide: C~21~H~26~BrNO~3~. Mw: 420.34. (1) Piperidinium, 3-[(hydroxydiphenylacetyl)oxy]-1,1-dimethyl-, bromide; (2) 3-Hydroxy-1,1-dimethylpiperidinium bromide benzilate. CAS-76-90-4; CAS-25990-43-6 (mepenzolate).
Pharmacologic Category
Anticholinergic Agents; Antimuscarinics/Antispasmodics. (ATC-Code: A03AB12).
Mechanism of action
Mepenzolate is a postganglionic parasympathetic inhibitor. Decreases gastric acid and pepsin secretion and suppresses spontaneous colon contractions.
Therapeutic use
Adjunctive treatment of peptic ulcer disease.
Pregnancy and lactiation implications
Teratogenic effects not observed in animal studies. There are no adequate studies in pregnant women. Might suppress lactation (use caution).
Unlabeled use
Contraindications
Hypersensitivity to mepenzolate or any component of the formulation. Angle-closure glaucoma. Obstructive uropathy (i.e. bladder neck obstruction due to prostatic hyperplasia). Obstructive GI disease (i.e. pyloroduodenal stenosis, achalasia). Paralytic ileus. Intestinal atony of the debilitated or elderly patient. Unstable cardiovascular status in acute hemorrhage. Severe ulcerative colitis or toxic megacolon complicating ulcerative colitis. Myasthenia gravis. Allergic or idiosyncratic reactions of related compounds.
Warnings and precautions
Might cause drowsiness and/or blurred vision. Diarrhea might be sign of incomplete intestinal obstruction. Risk of heat prostration in increased environmental temperature. Psychosis reported in extreme sensitivity to anticholinergic effects or at excessive dosages. Use with caution in coronary artery disease, tachyarrhythmias, heart failure, or hypertension. Use of anticholinergics in gastric ulcer treatment may cause delay in gastric emptying due to antral statis. Use with caution in hepatic/renal impairment, in hiatal hernia with reflux esophagitis, in hyperthyroidism, in autonomic neuropathy, in prostatic hyperplasia, in ulcerative colitis (might precipitate/aggravate toxic megacolon), and in the elderly (increased risk for anticholinergic effects, confusion, and hallucinations). Tablets contain tartrazine (might cause allergic reactions).