Mephobarbital (Methylphenobarbital)
- Atc Codes:N03AA01
- CAS Codes:115-38-8
- PHARMGKB ID:115-38-8
Table of contents
- Brand Names
- Chemistry
- Pharmacologic Category
- Mechanism of Action
- Therapeutic Use
- Contraindications
- Warnings and Precautions
- Adverse Reactions
- Caution and personalized dose adjustment in patients with the following genotypes
- Other genes that may be involved
- Substrate of
- Inhibits
- Induces
- Drug Interactions
- Dosage
- Pharmacokinetics and Pharmacodynamics
- Special Considerations
Brand Names
Europe
Slovenia: Phemiton.
North America
Canada: Mebaral (d); USA: Mebaral (d).
Drug combinations
Chemistry
Mephobarbital: C~13~H~14~N~2~O~3~. Mw: 246.26. (1) 2,4,6(1H,3H,5H)-Pyrimidinetrione, 5-ethyl-1-methyl-5-phenyl-; (2) 5-Ethyl-1-methyl-5-phenylbarbituric acid. CAS-115-38-8.
Pharmacologic Category
Anticonvulsants; Barbiturates. Anxiolytics, Sedatives, and Hypnotics; Barbiturates. (ATC-Code: N03AA01).
Mechanism of action
Increases seizure threshold in motor cortex. Depresses monosynaptic and polysynaptic transmission in CNS.
Therapeutic use
Sedative. Treatment of grand mal and petit mal epilepsy.
Pregnancy and lactiation implications
Unlabeled use
Contraindications
Hypersensitivity to mephobarbital, other barbiturates, or any component of the formulation. Pre-existing CNS depression. Respiratory depression. Severe uncontrolled pain. History of porphyria. Pregnancy.
Warnings and precautions
Use with caution in renal impairment.