Mephobarbital (Methylphenobarbital)

Table of contents

  • Brand Names
  • Chemistry
  • Pharmacologic Category
  • Mechanism of Action
  • Therapeutic Use
  • Contraindications
  • Warnings and Precautions
  • Adverse Reactions
  • Caution and personalized dose adjustment in patients with the following genotypes
  • Other genes that may be involved
  • Substrate of
  • Inhibits
  • Induces
  • Drug Interactions
  • Dosage
  • Pharmacokinetics and Pharmacodynamics
  • Special Considerations

Brand Names


Slovenia: Phemiton.

North America

Canada: Mebaral (d); USA: Mebaral (d).

Drug combinations


Mephobarbital: C~13~H~14~N~2~O~3~. Mw: 246.26. (1) 2,4,6(1H,3H,5H)-Pyrimidinetrione, 5-ethyl-1-methyl-5-phenyl-; (2) 5-Ethyl-1-methyl-5-phenylbarbituric acid. CAS-115-38-8.

Pharmacologic Category

Anticonvulsants; Barbiturates. Anxiolytics, Sedatives, and Hypnotics; Barbiturates. (ATC-Code: N03AA01).

Mechanism of action

Increases seizure threshold in motor cortex. Depresses monosynaptic and polysynaptic transmission in CNS.

Therapeutic use

Sedative. Treatment of grand mal and petit mal epilepsy.

Pregnancy and lactiation implications

Unlabeled use


Hypersensitivity to mephobarbital, other barbiturates, or any component of the formulation. Pre-existing CNS depression. Respiratory depression. Severe uncontrolled pain. History of porphyria. Pregnancy.

Warnings and precautions

Use with caution in renal impairment.



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