Mesalamine (Mesalazine)
- Atc Codes:A07EC02
- CAS Codes:89-57-6
- PHARMGKB ID:89-57-6
Table of contents
- Brand Names
- Chemistry
- Pharmacologic Category
- Mechanism of Action
- Therapeutic Use
- Pregnancy and Lactation Implications
- Contraindications
- Warnings and Precautions
- Adverse Reactions
- Genes that may be involved
- Drug Interactions
- Dosage
- Pharmacokinetics and Pharmacodynamics
- Special Considerations
Brand Names
Europe
Austria: Claversal, Mesagran, Mezavant, Pentasa, Salofalk; Belgium: Claversal, Colitofalk, Mesalazine, Pentasa; Bulgaria: Mesafoam, Mesalazin, Pentasa, Salofalk; Cyprus: Asacol, Mesagin, Mezavant, Salofalk; Czech Republic: Asacol, Pentasa, Salofalk, Samezil; Denmark: Asacol, Mesasal, Mezavant, Pentasa; Estonia: Asacol, Pentasa, Salofalk; Finland: Asacol, Pentasa, Salofalk; France: Fivasa, Pentasa, Rowasa; Germany: Asacol, Claversal, Falk-Asa, Mesalazin, Mesalmin, Mezavant, Pentasa, Salo, Salofalk, Salogran; Greece: Asacol, Asalazin, Cronezil, Ectospasmol, Favorat, Laboxantryl, Mesagin, Mesalazine, Mezavant, Pentasa, Salofalk; Hungary: Pentasa, Salofalk, Xalazin; Ireland: Asacolon, Mezavant, Pentasa, Salofalk; Italy: Asacol, Asalex, Asamax, Asavixin, Claversal, Enteraproct, Enterasin, Lextrasa, Mesaflor, Mesalazina, Pentacol, Pentasa, Plimage, Proctasacol; Latvia: Asacol, Pentasa, Salofalk; Lithuania: Asacol, Pentasa, Salofalk; Luxembourg: Asacol, Claversal, Colitofalk, Pentasa; Malta: Asacol, Ipocol, Mesren, Pentacol, Pentasa, Salofalk; Netherlands: Asacol, Pentasa, Salofalk; Poland: Asacol, Asamax, Colitan, Jucolon, Mesalazyna, Pentasa, Salofalk, Samezil; Portugal: Asacol, Claversal, Pentasa, Salofalk; Romania: Pentasa, Salofalk; Slovakia: Pentasa, Salofalk; Slovenia: Asacol, Salofalk, Samezil; Spain: Claversal, Lixacol, Pentasa, Salofalk; Sweden: Asacol, Lixacol, Mesasal, Mezavant, Pentasa, Salofalk; UK: Asacol, Ipocol, Mezavant, Pentasa, Salofalk.
North America
Canada: Asacol, Mesasal, Mezavant, Novo-5 Asa, Pentasa, Salofalk; USA: Apriso, Asacol, Canasa, Lialda, Pentasa, Rowasa.
Latin America
Argentina: Bufexan, Exotran, Pentasa, Rectocalm, Suprimal-Temis Lostalo, Xalazina, Yolecol; Brazil: Asalit, Chron-Asa, Mesacol, Mesalazina; Mexico: Asacol, Pentasa, Salofalk, Seramine.
Drug combinations
Chemistry
Mesalamine: C~7~H~7~NO~3~. Mw: 153.14. (1) Benzoic acid, 5-amino-2-hydroxy-; (2) 5-Aminosalicylic acid. CAS-89-57-6 (1986).
Pharmacologic Category
Gastrointestinal Drugs; Anti-inflammatory Agents; 5-Aminosalicylic Acid Derivative. (ATC-Code: A07EC02).
Mechanism of action
Thought to modulate local chemical mediators of inflammatory response, especially leukotrienes, and also postulated to be a free radical scavenger or inhibitor of tumor necrosis factor.
Therapeutic use
Treatment and maintenance of remission of mildly- to moderately-active ulcerative colitis (oral). Treatment of active mild-to-moderate distal ulcerative colitis, proctosigmoiditis, or proctitis (rectal).
Pregnancy and lactiation implications
Animal studies have not demonstrated teratogenicity or fertility impairment. Mesalamine crosses placenta. Enters breast milk (use caution).
Unlabeled use
Contraindications
Hypersensitivity to mesalamine, aminosalicylates, salicylates, or any component of the formulation.
Warnings and precautions
Pancreatitis should be considered in new abdominal discomfort. Pericarditis or myocarditis reported (use with caution in patients predisposed to these conditions). Symptomatic worsening of colitis might occur. Might cause acute intolerance syndrome (cramping, acute abdominal pain, bloody diarrhea; sometimes fever, headache, rash). In males, oligospermia (rare, reversible) reported. Use with caution in hypersensitivity to sulfasalazine. Use caution in hepatic dysfunction (hepatic failure reported). Use with caution in active peptic ulcers. Patients with pyloric stenosis may have prolonged gastric retention of tablets, delaying release of mesalamine in colon. Use with caution in renal impairment or history of renal disease. Renal disease reported (use caution with other medications converted to mesalamine). Use with caution in the elderly (increased incidence of blood dyscrasias). Capsule might contain phenylalanine. Suppositories contain saturated vegetable fatty acid esters (contraindicated in allergy to these components). Enema contains potassium metabisulfite (might cause severe hypersensitivity reactions (i.e. anaphylaxis) in sulfite allergies).