Mesalamine (Mesalazine)

Table of contents

  • Brand Names
  • Chemistry
  • Pharmacologic Category
  • Mechanism of Action
  • Therapeutic Use
  • Pregnancy and Lactation Implications
  • Contraindications
  • Warnings and Precautions
  • Adverse Reactions
  • Genes that may be involved
  • Drug Interactions
  • Dosage
  • Pharmacokinetics and Pharmacodynamics
  • Special Considerations

Brand Names


Austria: Claversal, Mesagran, Mezavant, Pentasa, Salofalk; Belgium: Claversal, Colitofalk, Mesalazine, Pentasa; Bulgaria: Mesafoam, Mesalazin, Pentasa, Salofalk; Cyprus: Asacol, Mesagin, Mezavant, Salofalk; Czech Republic: Asacol, Pentasa, Salofalk, Samezil; Denmark: Asacol, Mesasal, Mezavant, Pentasa; Estonia: Asacol, Pentasa, Salofalk; Finland: Asacol, Pentasa, Salofalk; France: Fivasa, Pentasa, Rowasa; Germany: Asacol, Claversal, Falk-Asa, Mesalazin, Mesalmin, Mezavant, Pentasa, Salo, Salofalk, Salogran; Greece: Asacol, Asalazin, Cronezil, Ectospasmol, Favorat, Laboxantryl, Mesagin, Mesalazine, Mezavant, Pentasa, Salofalk; Hungary: Pentasa, Salofalk, Xalazin; Ireland: Asacolon, Mezavant, Pentasa, Salofalk; Italy: Asacol, Asalex, Asamax, Asavixin, Claversal, Enteraproct, Enterasin, Lextrasa, Mesaflor, Mesalazina, Pentacol, Pentasa, Plimage, Proctasacol; Latvia: Asacol, Pentasa, Salofalk; Lithuania: Asacol, Pentasa, Salofalk; Luxembourg: Asacol, Claversal, Colitofalk, Pentasa; Malta: Asacol, Ipocol, Mesren, Pentacol, Pentasa, Salofalk; Netherlands: Asacol, Pentasa, Salofalk; Poland: Asacol, Asamax, Colitan, Jucolon, Mesalazyna, Pentasa, Salofalk, Samezil; Portugal: Asacol, Claversal, Pentasa, Salofalk; Romania: Pentasa, Salofalk; Slovakia: Pentasa, Salofalk; Slovenia: Asacol, Salofalk, Samezil; Spain: Claversal, Lixacol, Pentasa, Salofalk; Sweden: Asacol, Lixacol, Mesasal, Mezavant, Pentasa, Salofalk; UK: Asacol, Ipocol, Mezavant, Pentasa, Salofalk.

North America

Canada: Asacol, Mesasal, Mezavant, Novo-5 Asa, Pentasa, Salofalk; USA: Apriso, Asacol, Canasa, Lialda, Pentasa, Rowasa.

Latin America

Argentina: Bufexan, Exotran, Pentasa, Rectocalm, Suprimal-Temis Lostalo, Xalazina, Yolecol; Brazil: Asalit, Chron-Asa, Mesacol, Mesalazina; Mexico: Asacol, Pentasa, Salofalk, Seramine.

Drug combinations


Mesalamine: C~7~H~7~NO~3~. Mw: 153.14. (1) Benzoic acid, 5-amino-2-hydroxy-; (2) 5-Aminosalicylic acid. CAS-89-57-6 (1986).

Pharmacologic Category

Gastrointestinal Drugs; Anti-inflammatory Agents; 5-Aminosalicylic Acid Derivative. (ATC-Code: A07EC02).

Mechanism of action

Thought to modulate local chemical mediators of inflammatory response, especially leukotrienes, and also postulated to be a free radical scavenger or inhibitor of tumor necrosis factor.

Therapeutic use

Treatment and maintenance of remission of mildly- to moderately-active ulcerative colitis (oral). Treatment of active mild-to-moderate distal ulcerative colitis, proctosigmoiditis, or proctitis (rectal).

Pregnancy and lactiation implications

Animal studies have not demonstrated teratogenicity or fertility impairment. Mesalamine crosses placenta. Enters breast milk (use caution).

Unlabeled use


Hypersensitivity to mesalamine, aminosalicylates, salicylates, or any component of the formulation.

Warnings and precautions

Pancreatitis should be considered in new abdominal discomfort. Pericarditis or myocarditis reported (use with caution in patients predisposed to these conditions). Symptomatic worsening of colitis might occur. Might cause acute intolerance syndrome (cramping, acute abdominal pain, bloody diarrhea; sometimes fever, headache, rash). In males, oligospermia (rare, reversible) reported. Use with caution in hypersensitivity to sulfasalazine. Use caution in hepatic dysfunction (hepatic failure reported). Use with caution in active peptic ulcers. Patients with pyloric stenosis may have prolonged gastric retention of tablets, delaying release of mesalamine in colon. Use with caution in renal impairment or history of renal disease. Renal disease reported (use caution with other medications converted to mesalamine). Use with caution in the elderly (increased incidence of blood dyscrasias). Capsule might contain phenylalanine. Suppositories contain saturated vegetable fatty acid esters (contraindicated in allergy to these components). Enema contains potassium metabisulfite (might cause severe hypersensitivity reactions (i.e. anaphylaxis) in sulfite allergies).



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