Methacholine
- Atc Codes:V04CX
- CAS Codes:62-51-1#55-92-5
- PHARMGKB ID:62-51-1#55-92-5
Table of contents
- Brand Names
- Chemistry
- Pharmacologic Category
- Mechanism of Action
- Therapeutic Use
- Pregnancy and Lactation Implications
- Contraindications
- Warnings and Precautions
- Adverse Reactions
- Caution and personalized dose adjustment in patients with the following genotypes
- Other genes that may be involved
- Drug Interactions
- Dosage
Brand Names
Europe
Germany: Lindo, Nabit, Provokit; Italy: Metacolina; Spain: Provocholine.
North America
Canada: Methacholine, Provocholine; USA: Provocholine.
Drug combinations
Chemistry
Methacholine Chloride: C~8~H~18~ClNO~2~. Mw: 195.69. (1) 1-Propanaminium, 2-(acetyloxy)-N,N,N-trimethyl-, chloride, (±)-; (2)(±)-(2-Hydroxypropyl)trimethylammonium chloride acetate. CAS-62-51-1; CAS-55-92-5 (methacholine).
Pharmacologic Category
Diagnostic Agents; Respiratory Function. (ATC-Code: V04CX).
Mechanism of action
Stimulates muscarinic, postganglionic parasympathetic receptors, which results in smooth muscle contraction of airways and increased tracheobronchial secretions.
Therapeutic use
Diagnosis of bronchial airway hyperactivity.
Pregnancy and lactiation implications
Avoid use in pregnant women unless potential benefit justifies potential risk to fetus. Administration should be within 10 days of onset of menses or within 2 weeks of negative pregnancy test. Use not recommended during lactation.
Unlabeled use
Contraindications
Hypersensitivity to methacholine, other parasympathomimetic agents, or any component of the formulation. Concomitant use of β-blockers. Repeat administration (other than day of challenge test with increasing doses).
Warnings and precautions
Severe bronchoconstriction and reduction in respiratory function can result. Use only in cardiovascular disease, peptic ulcer disease, seizures, thyroid disease, urinary tract obstruction, and vagotonia if benefit outweighs risk. Methacholine is bronchoconstrictor for diagnostic purposes only. Product should not be handled by persons with asthma or hay fever.