Methocarbamol
- Atc Codes:M03BA03
- CAS Codes:532-03-6
- PHARMGKB ID:532-03-6
Table of contents
- Brand Names
- Drug Combinations
- Chemistry
- Pharmacologic Category
- Mechanism of Action
- Therapeutic Use
- Pregnancy and Lactation Implications
- Contraindications
- Warnings and Precautions
- Adverse Reactions
- Inhibits
- Drug Interactions
- Nutrition/Nutraceutical Interactions
- Dosage
- Pharmacokinetics and Pharmacodynamics
Brand Names
Europe
France: Lumirelax; Germany: Methocarbamol, Ortoton; Poland: Methocarbamol; Spain: Robaxin; UK: Robaxin.
North America
Canada: Methocarbamol, Robaxin; USA: Methocarbamol, Robaxin.
Latin America
Mexico: Rexivin.
Asia
Japan: Robaxin.
Drug combinations
Methocarbamol and Acetaminophen
Methocarbamol and Aspirin
Chemistry
Methocarbamol: C~11~H~15~NO~5~. Mw: 241.24. (1) 1,2-Propanediol, 3-(2-methoxyphenoxy)-, 1-carbamate, (±)-; (2)(±)-3-(o-Methoxyphenoxy)-1,2-propanediol 1-carbamate. CAS-532-03-6.
Pharmacologic Category
Centrally Acting Skeletal Muscle Relaxants. (ATC-Code: M03BA03).
Mechanism of action
Causes skeletal muscle relaxation by general CNS depression.
Therapeutic use
Treatment of muscle spasm associated with acute painful musculoskeletal conditions. Supportive therapy in tetanus. Treatment of muscle spasm associated with acute temporomandibular joint pain.
Pregnancy and lactiation implications
Animal reproduction studies not conducted. Use during pregnancy only if clearly needed. Excretion in breast milk unknown (use caution).
Unlabeled use
Contraindications
Hypersensitivity to methocarbamol or any component of the formulation. Renal impairment (injection formulation).
Warnings and precautions
Might cause CNS depression. Use with caution in hepatic or renal impairment. Use injection with caution in history of seizure disorder. Effects might be potentiated when used with other sedative drugs or ethanol. Solution is hypertonic (avoid extravasation). Vial stopper contains latex.