Methyclothiazide
- Atc Codes:C03AA08
- CAS Codes:135-07-9
- PHARMGKB ID:135-07-9
Table of contents
- Brand Names
- Drug Combinations
- Chemistry
- Pharmacologic Category
- Mechanism of Action
- Therapeutic Use
- Pregnancy and Lactation Implications
- Contraindications
- Warnings and Precautions
- Adverse Reactions
- Genes that may be involved
- Drug Interactions
- Nutrition/Nutraceutical Interactions
- Dosage
- Pharmacokinetics and Pharmacodynamics
- Special Considerations
Brand Names
North America
USA: Enduron, Methyclothiazide.
Drug combinations
Methyclothiazide and Triamterene
Chemistry
Methyclothiazide: C~9~H~11~Cl~2~N~3~O~4~S~2~. Mw: 360.24. (1) 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3-(chloromethyl)-3,4-dihydro-2-methyl-, 1,1-dioxide, (±)-; (2)(±)-6-Chloro-3-(chloromethyl)-3,4-dihydro-2-methyl-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide. CAS-135-07-9 (1963).
Pharmacologic Category
Thiazide Diuretics. (ATC-Code: C03AA08).
Mechanism of action
Inhibits sodium reabsorption in distal tubules causing increased excretion of sodium and water, as well as potassium and hydrogen ions.
Therapeutic use
Management of mild-to-moderate hypertension. Treatment of edema in congestive heart failure and nephrotic syndrome.
Pregnancy and lactiation implications
Use caution when administered during pregnancy or lactation.
Unlabeled use
Contraindications
Hypersensitivity to methyclothiazide or any component, thiazides, or sulfonamide-derived drugs. Anuria. Renal decompensation.
Warnings and precautions
Electrolyte disturbances (hypokalemia, hypochloremic alkalosis, and hyponatremia) can occur. Photosensitization might occur. Use in thiazide or sulfonamide allergy contraindicated. Use with caution in prediabetes or diabetes mellitus (change in glucose control). Gout can be precipitated in certain patients. Use with caution in severe hepatic dysfunction, in moderate or high cholesterol concentrations, or in hypokalemia. Avoid in severe renal disease (ineffective). Can cause systemic lupus erythematosus exacerbation or activation.