Table of contents

  • Brand Names
  • Drug Combinations
  • Chemistry
  • Pharmacologic Category
  • Mechanism of Action
  • Therapeutic Use
  • Pregnancy and Lactation Implications
  • Contraindications
  • Warnings and Precautions
  • Adverse Reactions
  • Genes that may be involved
  • Drug Interactions
  • Nutrition/Nutraceutical Interactions
  • Dosage
  • Pharmacokinetics and Pharmacodynamics
  • Special Considerations

Brand Names

North America

USA: Enduron, Methyclothiazide.

Drug combinations

Methyclothiazide and Triamterene


Methyclothiazide: C~9~H~11~Cl~2~N~3~O~4~S~2~. Mw: 360.24. (1) 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3-(chloromethyl)-3,4-dihydro-2-methyl-, 1,1-dioxide, (±)-; (2)(±)-6-Chloro-3-(chloromethyl)-3,4-dihydro-2-methyl-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide. CAS-135-07-9 (1963).

Pharmacologic Category

Thiazide Diuretics. (ATC-Code: C03AA08).

Mechanism of action

Inhibits sodium reabsorption in distal tubules causing increased excretion of sodium and water, as well as potassium and hydrogen ions.

Therapeutic use

Management of mild-to-moderate hypertension. Treatment of edema in congestive heart failure and nephrotic syndrome.

Pregnancy and lactiation implications

Use caution when administered during pregnancy or lactation.

Unlabeled use


Hypersensitivity to methyclothiazide or any component, thiazides, or sulfonamide-derived drugs. Anuria. Renal decompensation.

Warnings and precautions

Electrolyte disturbances (hypokalemia, hypochloremic alkalosis, and hyponatremia) can occur. Photosensitization might occur. Use in thiazide or sulfonamide allergy contraindicated. Use with caution in prediabetes or diabetes mellitus (change in glucose control). Gout can be precipitated in certain patients. Use with caution in severe hepatic dysfunction, in moderate or high cholesterol concentrations, or in hypokalemia. Avoid in severe renal disease (ineffective). Can cause systemic lupus erythematosus exacerbation or activation.



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