Use caution with history of severe anaphylaxis to allergens. In general, patients with bronchospastic disease should not receive β-blockers. Use with caution in diabetes mellitus (might potentiate hypoglycemia and/or mask signs and symptoms), in compensated heart failure, in myasthenia gravis, in peripheral vascular disease (including Raynaud’s), and in history of psychiatric illness (may cause or exacerbate CNS depression). Some products may contain benzalkonium chloride which may be absorbed by soft contact lenses. β-blocker therapy should not be withdrawn abruptly (particularly in coronary artery disease). Systemic absorption and adverse effects might occur with ophthalmic use, including bradycardia and/or hypotension.