Table of contents

  • Brand Names
  • Chemistry
  • Pharmacologic Category
  • Therapeutic Use
  • Pregnancy and Lactation Implications
  • Contraindications
  • Warnings and Precautions
  • Adverse Reactions
  • Genes that may be involved
  • Substrate of
  • Inhibits
  • Induces
  • Drug Interactions
  • Dosage

Brand Names


France: Metopirone; Greece: Metopirone; Ireland: Metopirone; Malta: Metopirone; Netherlands: Metopiron; Sweden: Metopiron; UK: Metopirone.

North America

USA: Metopirone.


Japan: Metopiron.

Drug combinations


Metyrapone: C~14~H~14~N~2~O. Mw: 226.27. (1) 1-Propanone, 2-methyl-1,2-di-3-pyridinyl-; (2) 2-Methyl-1,2-di-3-pyridyl-1-propanone. CAS-54-36-4 (1963).

Metyrapone Tartrate: C~14~H~14~N~2~O 2C~4~H~6~O~6~. Mw: 526.45. (1) 1-Propanone, 2-methyl-1,2-di-3-pyridinyl-, [R-(R*,R*)]-2,3-dihydroxybutanedioate (1:2). CAS-908-35-0 (1966).

Pharmacologic Category

Diagnostic Agents; Pituitary Function. (ATC-Code: V04CD01).

Mechanism of action

Therapeutic use

Diagnostic test for hypothalamic-pituitary ACTH function.

Pregnancy and lactiation implications

Use during pregnancy only if clearly needed. Subnormal response may occur in pregnant women and fetal pituitary may be affected. Excretion in breast milk unknown (use caution).

Unlabeled use


Hypersensitivity to metyrapone or any component of the formulation. Adrenal cortical insufficiency.

Warnings and precautions

Might cause CNS depression. Acute adrenal insufficiency may be induced in reduced adrenal secretory capacity. Response to test may be subnormal in hyper-/hypothyroidism.



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