Midodrine
- Atc Codes:C01CA17
- CAS Codes:3092-17-9#42794-76-3
- PHARMGKB ID:3092-17-9#42794-76-3
Table of contents
- Brand Names
- Chemistry
- Pharmacologic Category
- Mechanism of Action
- Therapeutic Use
- Unlabeled Use
- Pregnancy and Lactation Implications
- Contraindications
- Warnings and Precautions
- Adverse Reactions
- Genes that may be involved
- Drug Interactions
- Dosage
- Pharmacokinetics and Pharmacodynamics
- Special Considerations
Brand Names
Europe
Austria: Gutron; Bulgaria: Gutron; Czech Republic: Gutron; France: Gutron; Germany: Gutron; Greece: Gutron; Hungary: Gutron; Ireland: Midon; Italy: Gutron, Rodom, Xerotil; Lithuania: Gutron; Netherlands: Gutron; Poland: Gutron; Portugal: Gutron; Romania: Gutron; Slovakia: Gutron; Spain: Gutrón.
North America
Canada: Amatine, Midodrine; USA: Midodrine, Orvaten, Proamatine.
Latin America
Argentina: Gutrón.
Asia
Japan: Abalnate, Metligine, Metodrin, Natildine, Shuprase.
Drug combinations
Chemistry
Midodrine Hydrochloride: C~12~H~18~N~2~O~4~ HCl. Mw: 290.74. (1) Acetamide, 2-amino-N-[2-(2,5-dimethoxyphenyl)-2-hydroxyethyl]-, monohydrochloride, (±)-; (2)(±)-2-Amino-N-(β-hydroxy-2,5-dimethoxyphenethyl)acetamide monohydrochloride. CAS-3092-17-9; CAS-42794-76-3 (midodrine)(1983).
Pharmacologic Category
Sympathomimetic (Adrenergic) Agents; α-Adrenergic Agonists. (ATC-Code: C01CA17).
Mechanism of action
Midodrine forms an active metabolite, desglymidodrine, an α~1~-agonist. This agent increases arteriolar and venous tone resulting in a rise in standing, sitting, and supine systolic and diastolic blood pressure in orthostatic hypotension.
Therapeutic use
Orphan drug: Treatment of symptomatic orthostatic hypotension.
Pregnancy and lactiation implications
Increased rate of embryo resorption and decreased fetal weight observed in animal studies. Use during pregnancy should be avoided unless potential benefit outweighs risk to fetus. Excretion in breast milk unknown (use caution).
Unlabeled use
Investigational: Management of urinary incontinence.
Contraindications
Hypersensitivity to midodrine or any component of the formulation. Severe organic heart disease. Urinary retention. Pheochromocytoma. Thyrotoxicosis. Persistent and significant supine hypertension.
Warnings and precautions
Might cause hypertension. Use with caution in diabetes mellitus, hepatic impairment, or urinary retention. Use with caution in visual problems, especially if receiving fludrocortisone. Use not recommended with supine hypertension.