Monobenzone
- Atc Codes:D11AX13
- CAS Codes:103-16-2
- PHARMGKB ID:103-16-2
Table of contents
- Brand Names
- Chemistry
- Pharmacologic Category
- Mechanism of Action
- Therapeutic Use
- Pregnancy and Lactation Implications
- Contraindications
- Warnings and Precautions
- Adverse Reactions
- Genes that may be involved
- Drug Interactions
- Dosage
Brand Names
Europe
Poland: Monobenzone.
North America
Canada: Benoquin.
Drug combinations
Chemistry
Monobenzone: C~13~H~12~O~2~. Mw: 200.23. (1) Phenol, 4-(phenylmethoxy)-; (2) p-(Benzyloxy)phenol. CAS-103-16-2.
Pharmacologic Category
Depigmenting Agents. Topical Skin Product. (ATC-Code: D11AX13).
Mechanism of action
Increases excretion of melanin from melanocytes. Causes melanocyte destruction and permanent depigmentation.
Therapeutic use
Final depigmentation in extensive vitiligo.
Pregnancy and lactiation implications
Animal reproduction studies not conducted. Excretion in breast milk unknown (use caution).
Unlabeled use
Contraindications
Hypersensitivity to monobenzone or any component of the formulation. Use as cosmetic skin bleach. Use as hydroquinone substitute.
Warnings and precautions
Photosensitivity. For external use only. Not recommended for use in freckling, hyperpigmentation caused by photosensitization, melasma, hyperpigmentation resulting from skin inflammation, cafe-au-lait spots, pigmented nevi, or malignant melanoma.