Anaphylactic and anaphylactoid reactions may occur. Acute hypersensitivity reactions (cardiovascular collapse, cardiorespiratory arrest, loss of consciousness, shock, tachycardia, tingling, angioedema, airway obstruction, bronchospasm, dyspnea, urticaria, and pruritus). CNS events (seizures, encephalopathy, cerebral edema, aseptic meningitis, and headache) reported. Contraindicated for use in history of seizures or patients predisposed to seizures. Cytokine release syndrome may occur following first couple of doses. Possible increased susceptibility to infection. Increased risk of development of lymphoproliferative disorders (particularly of skin). Severe pulmonary edema occurred with fluid overload. Arterial, venous, and capillary thrombosis of allografts and other vascular beds reported (use with caution in history of thrombosis or underlying vascular disease). May result in an increased susceptibility to infection.