Nabilone
- Atc Codes:A04AD11
- CAS Codes:51022-71-0
- PHARMGKB ID:51022-71-0
Table of contents
- Brand Names
- Chemistry
- Pharmacologic Category
- Mechanism of Action
- Therapeutic Use
- Pregnancy and Lactation Implications
- Contraindications
- Warnings and Precautions
- Adverse Reactions
- Genes that may be involved
- Drug Interactions
- Dosage
- Pharmacokinetics and Pharmacodynamics
- Special Considerations
Brand Names
Europe
UK: Nabilone.
North America
Canada: Cesamet; USA: Cesamet.
Latin America
Argentina: Cesamet; Mexico: Cesamet.
Drug combinations
Chemistry
Nabilone: C~24~H~36~O~3~. Mw: 372.54. (1) 9H-Dibenzo[b,d]pyran-9-one, 3-(1,1-dimethylheptyl)-6,6a,7,8,10,10a-hexahydro-1-hydroxy-6,6-dimethyl-, trans-, (±)-; (2)(±)-3-(1,1-Dimethylheptyl-6,6aβ,7,8,10,10aα-hexahydro-1-hydroxy-6,6-dimethyl-9H-dibenzo[b,d]pyran-9-one. CAS-51022-71-0 (1976).
Pharmacologic Category
Antiemetics, Miscellaneous. (ATC-Code: A04AD11).
Mechanism of action
May be due to effect on cannabinoid receptors (CB~1~) within CNS.
Therapeutic use
Treatment of refractory nausea and vomiting associated with cancer chemotherapy.
Pregnancy and lactiation implications
Use during pregnancy only if clearly needed. Use in breast-feeding not recommended.
Unlabeled use
Contraindications
Hypersensitivity to nabilone, cannabinoids or tetrahydrocannabinol.
Warnings and precautions
May cause tachycardia and/or orthostatic hypotension. May impair physical or mental abilities. Use with caution in history of drug abuse or acute alcoholism (potential for drug dependency exists). Tolerance, psychological and physical dependence may occur with prolonged use. Use with caution in mania, depression, or schizophrenia. Effects may be potentiated when used with other psychoactive drugs, sedatives and/or ethanol.