Neomycin
- Atc Codes:A01AB08#A07AA01#B05CA09#D06AX04#J01GB05#R02AB01#S01AA03#S02AA07#S03AA01
- CAS Codes:119-04-0
- PHARMGKB ID:119-04-0
Table of contents
- Brand Names
- Drug Combinations
- Chemistry
- Pharmacologic Category
- Mechanism of Action
- Therapeutic Use
- Pregnancy and Lactation Implications
- Contraindications
- Warnings and Precautions
- Adverse Reactions
- Toxicological Effects
- Drug Interactions
- Dosage
- Pharmacokinetics and Pharmacodynamics
- Special Considerations
Brand Names
Europe
Bulgaria: Neomycinum TC; Germany: Cysto-Myacyne N, Myacyne-Salbe, Neo-S, Neomy, Neomycin, Uro-Nebacetin N, Vagicillin; Greece: Neomicina, Neomycin; Hungary: Dexapolcort-N, Mycerin, Neomycin; Italy: Neomic S; Luxembourg: Fradyl, Neomycine; Netherlands: Neomycinesulfaat; Poland: Neomycini, Neomycinum; Portugal: Enteromicina, Neomicina; Slovenia: Bivacyn; Spain: Neomicina; UK: Nivemycin.
North America
USA: Neo-Fradin.
Latin America
Argentina: Concatag, Neomas Bowers; Brazil: Cinaderm, Nemicina, Neocina, Neodermicina, Neomed, Neomicin, Neomicon; Mexico: Neomixen, Otilin.
Asia
Japan: Dentargle, Fradiomycin, Sofratulle.
Drug combinations
Neomycin and Aluminum
Neomycin and Bacitracin
Neomycin and Cloxacillin
Neomycin and Dexamethasone
Neomycin and Fluocinolone
Neomycin and Fluorometholone
Neomycin and Hydrocortisone
Neomycin and Lincomycin
Neomycin and Loperamide
Neomycin and Metronidazole
Neomycin and Naphazoline
Neomycin and Penicillin G Procaine
Neomycin and Polymyxin B
Neomycin and Prednisolone
Neomycin and Streptomycin
Neomycin and Triamcinolone
Neomycin, Bacitracin, and Polymyxin B
Neomycin, Bacitracin, and Tyrothricin
Neomycin, Chloramphenicol, and Hydrocortisone
Neomycin, Chloramphenicol, and Phenylephrine
Neomycin, Clobetasol, and Nystatin
Neomycin, Dexamethasone, and Naphazoline
Neomycin, Dexamethasone, and Nystatin
Neomycin, Dexamethasone, and PolYmyxin B
Neomycin, Diphenhydramine, and Hydrocortisone
Neomycin, Fluorometholone, and Miconazole
Neomycin, Fluocinolone, and Polymyxin B
Neomycin, Gramicidin and Naphazoline
Neomycin, Halcinonide, and Nystatin
Neomycin, Hyaluronidase, and Lidocaine
Neomycin, Hydrocortisone, and Naphazoline
Neomycin, Hydrocortisone, and Polymyxin B
Neomycin, Metronidazole, and Nystatin
Neomycin, Nystatin, and Polymyxin B
Neomycin, Phenylephrine, and Polymyxin B
Neomycin, Prednisolone, and Polymyxin B
Neomycin, Prednisolone and Sulfacetamide
Neomycin, Antipyrine, Cetrimide, and Sodium Carbonate
Neomycin, Bacitracin, Hydrocortisone, and Polymyxin B
Neomycin, Bacitracin, Polymyxin B, and Pramoxine
Neomycin, Chlorpheniramine, Dexamethasone, and Naphazoline
Neomycin, Chlorpheniramine, Gramicidin, and Phenylephrine
Neomycin, Dexamethasone, Lidocaine, and Polymyxin B
Neomycin, Fludrocortisone, Lidocaine, and Polimyxin B
Neomycin, Gramicidin, Nystatin, and Triamcinolone
Neomycin, Colistin Sulfate, Hydrocortisone, and Thonzonium Bromide
Neomycin, Dibucaine, Esculoside, and Hydrocortisone
Neomycin, Hydrocortisone, Lidocaine, and Retinol (Vitamin A)
Neomycin, Metronidazole, Miconazole, and Polymyxin B
Neomycin, Nitrofurazone, Nystatin, and Retinol (Vitamin A)
Neomycin, Nystatin, Thiostrepton, and Triamcinolone
Neomycin, Dexamethasone, Lidocaine, Metronidazole, and Nystatin
Neomycin, Gotu Kola, Metronidazole, Miconazole, and Polymyxin B
Neomycin, Diflorasone, Econazole, Gentamicin, Griseofulvin, Hydrocortisone, and Salicylic Acid
Other Neomycin combinations: Cysteine; Ergocalciferol (Vitamin D~2~)
Chemistry
Neomycin: C~23~H~46~N~6~O~13~. Mw: 614.64. (1R,2R,3S,4R,6S)-4,6-diamino-2-{[3-O-(2,6-diamino-2,6-dideoxy-β-L-idopyranosyl)-D-ribofuranosyl]oxy}-3-hydroxycyclohexyl 2,6-diamino-2,6-dideoxy-α-D-glucopyranoside. CAS-119-04-0.
Pharmacologic Category
Antibacterials; Aminoglycosides. EENT Preparations; Antibacterials. Skin and Mucous Membrane Agents; Antibacterials. Ammonia Detoxicants. Topical Antibiotic. (ATC-Code: A01AB08; A07AA01; B05CA09; D06AX04; J01GB05; R02AB01; S01AA03; S02AA07; S03AA01).
Mechanism of action
Interferes with bacterial protein synthesis by binding to 30S ribosomal subunits.
Therapeutic use
Preparation of gastrointestinal tract for surgery. Treatment of minor skin infections. Treatment of diarrhea caused by E. coli. Adjunct in treatment of hepatic encephalopathy. Bladder irrigation. Ocular infections.
Pregnancy and lactiation implications
Neomycin crosses placenta. No reports of fetal toxicity in humans from neomycin. No adequate, well-controlled studies conducted in pregnant women, and unknown whether neomycin can cause fetal harm. Unknown if neomycin is excreted into breast milk. Non-dose-related effects could include modification of bowel flora.
Unlabeled use
Contraindications
Hypersensitivity to neomycin or any component of the formulation, or other aminoglycosides. Intestinal obstruction.
Warnings and precautions
May cause nephrotoxicity (usual risk factors include pre-existing renal impairment, concomitant nephrotoxic medications, advanced age and dehydration). May cause neuromuscular blockade and respiratory paralysis (especially when given soon after anesthesia or muscle relaxants). May cause neurotoxicity (usual risk factors include pre-existing renal impairment, concomitant neuro-/nephrotoxic medications, advanced age and dehydration). Ototoxicity proportional to amount of drug given and duration of treatment. Tinnitus or vertigo may be indications of vestibular injury and impending bilateral irreversible damage. Prolonged use may result in fungal or bacterial superinfection, including C. difficile-associated diarrhea and pseudomembranous colitis. Use with caution in pre-existing vertigo, tinnitus, or hearing loss; in neuromuscular disorders, including myasthenia gravis, and in pre-existing renal insufficiency. Should not be administered parenterally (more toxic than other aminoglycosides). Should not be used as peritoneal lavage due to significant systemic adsorption of drug.