Niacinamide (Nicotinamide)
- Atc Codes:A11HA01
- CAS Codes:98-92-0
- PHARMGKB ID:98-92-0
Table of contents
- Brand Names
- Drug Combinations
- Chemistry
- Pharmacologic Category
- Mechanism of Action
- Therapeutic Use
- Pregnancy and Lactation Implications
- Contraindications
- Warnings and Precautions
- Adverse Reactions
- Genes that may be involved
- Drug Interactions
- Dosage
- Pharmacokinetics and Pharmacodynamics
Brand Names
Europe
Belgium: Ucemine PP; France: Nicobion, Vitamine PP; Germany: Nicotinsäureamid; Ireland: Nicam; Italy: Nicotinamide; Luxembourg: Ucemine PP; Netherlands: Nicotinamide; Poland: Vitaminum PP; UK: Freederm, Nicam.
North America
Canada: Niacinamide.
Latin America
Argentina: Lumisol Serum; Brazil: Papuless; Mexico: Nacro.
Asia
Japan: Nicotinamid.
Drug combinations
Niacinamide and Mepivacaine
Niacinamide, Dexamethasone, and Pyridoxine (Vitamin B~6~)
Niacinamide, Dibucaine, and Diphenhydramine
Niacinamide, Mepivacaine, and Polyestradiol
Other Niacinamide combinations: Aloe vera; Ascorbic Acid (Vitamin C); B-Alanine; Beta-Carotene; Biotin (Vitamin B~7~); Caffeine; Calcium Carbonate; Calcium Lactate; Calcium Phosphate; Centella asiatica; Cysteine; Chamomile; Cholecalciferol (Vitamin D~3~); Chromium; Coenzyme Q~10~; Copper Sulfate; Cyanocobalamin (Vitamin B~12~); Cyproheptadine; Cystine; Dexamethasone; Ergocalciferol (Vitamin D~2~); Eucalyptus globulus; Ferrous Fumarate; Ferrous Sulfate; Folic Acid (Vitamin B~9~); Ginkgo biloba; Ginseng; Hawthorn; Inositol; Iron; L-Arginine; L-Carnitine; L-Histidine; L-Isoleucine; L-Leucine; L-Lysine; L-Valine; Magnesium Oxide; Manganese; Methionine; Molybdenum; Niacin (Vitamin B~3~); Pantothenic Acid (Vitamin B~5~); Paullinia cupana; Phosphorus; Phytonadione (Vitamin K~1~); Pollen; Potassium; Procaine; Pyridoxine (Vitamin B~6~); Retinol (Vitamin A); Riboflavin (Vitamin B~2~); Rutoside; Saccharomyces cerevisiae; Selenium; Sodium; Soy Protein; Taurine; Thiamine (Vitamin B~1~); Tocopherol (Vitamin E); Zinc; Zinc Oxide
Chemistry
Niacinamide: C~6~H~6~N~2~O. Mw: 122.12. 3-Pyridinecarboxamide. CAS-98-92-0.
Pharmacologic Category
Vitamins; Vitamin B Complex. (ATC-Code: A11HA01).
Mechanism of action
Used by body as source of niacin. A component of two coenzymes necessary for tissue respiration, lipid metabolism, and glycogenolysis. Niacinamide has anti-inflammatory properties, believed to help decrease inflammatory acne lesions.
Therapeutic use
Prophylaxis and treatment of pellagra. Improving appearance of acne and decreasing visible inflammation and irritation caused by acne medications.
Pregnancy and lactiation implications
Use with caution in pregnant and nursing women.
Unlabeled use
Contraindications
Hypersensitivity to niacin, niacinamide, or any component of the formulation. Liver disease. Active peptic ulcer.
Warnings and precautions
Use with caution in allergies, renal impairment, heavy ethanol users or predisposition to gout. Use with caution in unstable angina or coronary artery disease (risk of arrhythmias at high doses). Use with caution in diabetes mellitus (interferes with glucose control), and in active gallbladder disease (can be exacerbated). Avoid large pharmacological amounts in history of liver disease.