Nitrendipine
- Atc Codes:C08CA08
- CAS Codes:39562-70-4
- PHARMGKB ID:39562-70-4
Table of contents
- Brand Names
- Drug Combinations
- Chemistry
- Pharmacologic Category
- Mechanism of Action
- Therapeutic Use
- Pregnancy and Lactation Implications
- Contraindications
- Warnings and Precautions
- Adverse Reactions
- Toxicological Effects
- Genes that may be involved
- Substrate of
- Inhibits
- Drug Interactions
- Nutrition/Nutraceutical Interactions
- Dosage
- Pharmacokinetics and Pharmacodynamics
- Special Considerations
Brand Names
Europe
Austria: Baypress; Belgium: Baypress; Bulgaria: Nitrendipin, Ravena; Czech Republic: Baypress, Lusopress, Nitrendipin, Nitrepress, Nitresan, Unipres; Denmark: Baypress; Estonia: Lusopress, Nitresan; France: Baypress, Nidrel, Nitrendipine; Germany: Bayotensin, Baypress, Jutapress, Nitre-PUREN, Nitregamma, Nitren Lich, Nitrendidoc, Nitrendipin, Nitrensal, Nitresan, Nitripress; Greece: Baypress, Lostradyl, Nelconil, Potional; Hungary: Baypress, Nevin, Unipress; Italy: Baypress; Latvia: Lusopress, Nitresan; Lithuania: Lusopress, Nitresan; Luxembourg: Baypress; Netherlands: Baypress; Poland: Baypress, Nitrendypina, Nitresan, Unipres; Portugal: Farnitran, Hyperdipina; Slovakia: Lusopress, Nitresan, Unipres; Slovenia: Unipres; Spain: Baypresol, Gericin, Niprina, Nitrendipino, Tensogradal, Vastensium.
Latin America
Argentina: Nirapel, Nitrendil; Brazil: Caltren, Nitrencord, Nitrendipino.
Asia
Japan: Balodipine, Balotein, Baylotensin, Bayniroad, Cobatensin, Dosperopin, Dowtensine, Ecatelisin, Ellenal, Hishiromin, Nilzipin, Nitopress, Nitotelocin, Nitrenal, Shetlazorna.
Drug combinations
Nitrendipine and Enalapril
Chemistry
Nitrendipine: C~18~H~20~N~2~O~6~. Mw: 360.36. (1) 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, ethyl methyl ester, (±)-; (2)(±)-Ethyl methyl 1,4dihydro-2,6-dimethyl-4-(m-nitrophenyl)-3,5-pyridinedicarboxylate. CAS-39562-70-4 (1981).
Pharmacologic Category
Calcium Channel-Blocking Agents; Dihydropyridines. (ATC-Code: C08CA08).
Mechanism of action
Dihydropyridine calcium channel-blocking agent with actions similar to nifedipine.
Therapeutic use
Hypertension.
Pregnancy and lactiation implications
Enters breast milk (not recommended).
Unlabeled use
Contraindications
Hypersensitivity to any component of the formulation or other calcium channel-blocking agents. Hypotension. Advanced aortic stenosis.
Warnings and precautions
Reduce dosage in the elderly. Caution in liver insufficiency, digital ischemia, nonobstructive hypertrophic cardiomyopathy, Duchenne muscular dystrophy, or in combination with β-blocking agents. Blood pressure lowering must be done at a rate appropriate for the patient’s clinical condition. May cause dizziness or fatigue.