Nonoxynol 9

Table of contents

  • Brand Names
  • Drug Combinations
  • Chemistry
  • Pharmacologic Category
  • Mechanism of Action
  • Therapeutic Use
  • Contraindications
  • Warnings and Precautions
  • Adverse Reactions
  • Dosage

Brand Names


Bulgaria: Patentex Oval; Czech Republic: Patentex Oval; Finland: Patentex Oval; Germany: Contraceptivum, Patentex Oval; Hungary: Patentex Oval; Latvia: Patentex Oval; Lithuania: Patentex Oval; Poland: Delfen, Patentex Oval, Preventex N 9; Portugal: Rendell’s.

North America

USA: Today Sponge.

Latin America

Brazil: Preserv Nonoxynol 9.

Drug combinations

Nonoxynol 9 and Povidone Iodine


Nonoxynol 9: C~15~H~24~O(C~2~H~4~O)~n~ (n~9). (1) Poly(oxy-1,2-ethanediyl), α-(4-nonylphenyl)-ω-hydroxy-; (2) Polyethylene glycol mono(p-nonylphenyl) ether; (3) α-(p-Nonylphenyl)-ω-hydroxynona(oxyethylene). CAS-26027-38-3 (1966).

Pharmacologic Category

Other Miscellaneous Therapeutic Agents; Contraceptive, Spermicide. (ATC-Code: G02BB).

Mechanism of action

Nonoxynol 9 is a surfactant which prevents pregnancy by damaging cell membrane of sperm. Some product formulations may also provide physical barrier.

Therapeutic use

Prevention of pregnancy.

Pregnancy and lactiation implications

Unlabeled use


Hypersensitivity to nonoxynol 9 or any component of the formulation.

Warnings and precautions

Toxic shock syndrome reported with barrier contraceptive use. May cause vaginal irritation (e.g. burning, itching or rash). Nonoxynol 9 does not protect against HIV infection or other sexually-transmitted diseases and use may increase risk of getting HIV from infected partner. Not for use in HIV or with sexual partner with HIV. Not for use as microbicide or lubricant during anal intercourse. Rectal use may cause irritation, which may increase risk of getting HIV from infected partner.



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