Ophthalmic solution: For topical ocular use only. As with any eye drop, to prevent contaminating the dropper tip and solution, care should be taken not to touch the eyelids or surrounding areas with the dropper tip of the bottle. Keep bottle tightly closed when not in use. Patients should be advised not to wear a contact lens if the eye is red. Should not be used to treat contact lens-related irritation. The preservative in olopatadine solution, benzalkonium chloride, may be absorbed by soft contact lenses (wait at least ten minutes after instilling solution before inserting contact lenses). Symptoms similar to cold syndrome and pharyngitis have been reported.

Nasal spray: May cause drowsiness in some patients; instruct patient to use caution when driving or operating machinery. Effects may be additive with CNS depressants and/or ethanol. Periodically examine nasal mucosa for ulceration and consider discontinuing if ulceration occurs.