Omeprazole

Table of contents

  • Brand Names
  • Drug Combinations
  • Chemistry
  • Pharmacologic Category
  • Mechanism of Action
  • Therapeutic Use
  • Unlabeled Use
  • Pregnancy and Lactation Implications
  • Contraindications
  • Warnings and Precautions
  • Adverse Reactions
  • Caution and personalized dose adjustment in patients with the following genotypes
  • Other genes that may be involved
  • Substrate of
  • Inhibits
  • Induces
  • Drug Interactions
  • Nutrition/Nutraceutical Interactions
  • Dosage
  • Pharmacokinetics and Pharmacodynamics
  • Special Considerations

Brand Names

Europe

Austria: Gastrobene, Gastroplex, Losec, Novek, Omec, Omepralan, Omeprazol, Omprezolin; Belgium: Docomepra, Losec, Omepracuremylan, Omeprazol, Omeprazole, Sedacid; Bulgaria: Bioprazol, Helicid, Omeprazol, Omeprazole, Probitor, Sopral, Ulcoprol, Ultop; Cyprus: Epirazole, Losec, Omedar, Omezol, Omisec; Czech Republic: Apo-Ome, Asilar, Gasec, Helicid, Lomac, Losec, Loseprazol, Omepirex, Omeprazol, Omolin, Onprelen, Ortanol, Tulzol, Ultop; Denmark: Losec, Omelix, Omeprazol; Estonia: Gasec Gastrocaps, Losec, Loseprazol, Omar, Omep, Omeprazol, Omeprazole, Omolin, Ultop; Finland: Gastrostad, Losec, Omeprazol, Omestad; France: Losec, Mopral, Omegen, Omelene, Omepcid, Omepirex, Omeprazole, Panazol, Zoltum; Germany: Gastroloc pro infusione, Gastromep, Losec, Magomep, Micromep, Oma, Ome, Omeloxan, Omep, Omepaz, Omepgastra, Omepol, Omepra, Omeprac, Omepradex, Omeprazol, Stomep, Ulcozol, Ulnor; Greece: Acromon, Alevior, Assoprol, Belifax, Benzol, Comoprazol, Diorium, Efrozin, Elcodrop, Elibactin, Elkostop, Elkotheran, Eselan, Esopraz, Ezipol, Flusal, Gastrol, Gastronorm, Genephazole, Gertalgin, Glaveral, Inhiplex, Kerlofin, Lanex-Lavipharm, Lenar, Lexigor, Lodrec, Loproc, Lordin, Losec, Lozaprin, Lyopraz, Malortil, Meprolen, Mezzole, Novek, Odamesol, Ofnimarex, Olark, Omepracure, Omeprazole, Omeprol, Omerane, Omezalin, Oprazium, Ortanol, Palser, Paon, Penrazol, Pip Acid, Prazolin, Probitor, Pronzek, Prozal, Rukuz, Rythmogastryl, Sedacid, Sieral, Silato, Sodeprol, Spezato, Ufonitren, Vamac, Veralox, Ziliprol, Zolandil, Zolelcon, Zolldenol, Zolmach; Hungary: Crismel, Losec, Ludea, Omegen, Omep, Omeprazol; Ireland: Bentome, Bysec, Davliet, Kalgriff, Lemowan, Lopraz, Losamel, Losapol, Losec, Losepine, Mylcer, Omeprazol, Omeprazole, Pugritex, Romep, Soothome, Tulzol, Ulcid; Italy: Alsidol, Anadir, Antra, Cletus, Ibimezolo, Komezol, Kruxagon, Limnos, Losec, Maricrio, Mepral, Nansen, Omeprazen, Omeprazolo, Omolin, Protec, Ulcezol; Lithuania: Gasec Gastrocaps, Ocid, Omep, Omeprazol, Omeprazole, Omeprazolis, Omolin, Ultop; Luxembourg: Lensor, Losec; Netherlands: Buscozol, Itomed, Loprilin, Losec, Moprilic, Omeprazol, Omolin, Omoquis, Prazigast, Romisan; Poland: Agastin, Bioprazol, Exter, Gasec, Helicid, Helisec, Losec, Loseprazol, Notis, Omar, Omepragal, Omeprawin, Omeprazol, Omeprazole, Ortanol, Piastprazol, Polprazol, Prazigast, Prazol, Progastim, Tulzol, Ulzol; Portugal: Albosan, Balzoprem, Bloprazol, Eugastrim, Gasec, Losec, Megazol, Mepraz, Novek, Omepra, Omeprazol, Omerax, Ometon, Omezolan, Ozime, Prazentol, Prazex, Prazolene, Proclor, Proton; Romania: Helicid, Losec, Novogast, Omedar, Omeprazol, Omeran, Omez, Ortanol, Risek, Ultop; Slovakia: Asilar, Helicid, Lomac, Losec, Loseprazol, Omeprazol, Omolin, Tevazol; Slovenia: Gasec, Omeprazol, Omolin, Ortanol, Ultop, Ulzol; Spain: Arapride, Audazol, Aulcer, Belmazol, Ceprandal, Dolintol, Elgam, Emeproton, Gastrimut, Indurgan, Ipirasa, Losec, Miol, Norpramin-UCB, Novek, Nuclosina, Omapren, Omeprazol, Ompranyt, Parizac, Pepticum, Prysma, Sanamidol, Ulceral, Ulcesep, Zimor; Sweden: Losec, Omedar, Omeprazol, Omestad; UK: Losec, Mepradec, Omeprazole.

North America

Canada: Losec, Omeprazole; USA: Omeprazole, Prilosec.

Latin America

Argentina: Acimed, Aziatop, Buscasan, Danlox, Faboacid Plus, Fabrazol, Fendiprazol, Gastec, Gastroprazol, Gastrotem, Klomeprax, Lafeprazol, Losec, Mucoxol, Oblisec, Omeprasec, Omeprazol, Pepticus, Pravil, Procelac, Prysma, Regulacid, Sedigastrol, Timezol, Ulcozol, Ulsanol, Veroprazol, Zoltenk; Brazil: Estomepe, Eupept, Gasec, Gaspiren, Gastrium, Gaztrozol, Klispel, Loprazol, Losec, Lozeprel, Neoprazol, Omegastrol, Omenax, Omepramed, Omeprazin, Omeprazol, Oprazon, Peprazol, Pepsicaps, Prazolex-Greenpharma, Prazonil, Ulcefor, Uniprazol, Victrix; Mexico: Alboz, Aleprozil, Apopraza, Danovag, Domer, Gerdex, Grizol, Hitrax, Ibax, Inhibitron, Logazil, Lopram, Losec, Medral, Melet, Mopral, Mornin, Olexin, Omecaps, Omeprazol, Ometec, Opramid, Osiren, Ozoken, Panzer, Pastrizol, Pentren, Prazidec, Prazolit, Promezal, Reux, Sarox, Silopral, Solcer, Suifac, Tarzol, Ucetal, Ulsen, Ultizol, Usaltron, Vulcasid, Zolufen, Zulmedx.

Asia

Japan: Enpral, Omepral, Omeprazole, Omeprazon, Omeproton, Omeptorol, Omerap, Ovulaze.

Drug combinations

Omeprazole and Ketoprofen

Omeprazole and Sodium Bicarbonate

Omeprazole, Amoxicillin, and Clarithromycin

Omeprazole, Magnesium Hydroxide, and Sodium Bicarbonate

Chemistry

Omeprazole: C~17~H~19~N~3~O~3~S. Mw: 345.42. (1) 1H-Benzimidazole, 5-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-; (2) 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]sulfinyl]benzimidazole. CAS-73590-58-6 (1986).

Pharmacologic Category

Antiulcer Agents and Acid Suppressants; Proton-pump Inhibitors. Substituted Benzimidazole. (ATC-Code: A02BC01).

Mechanism of action

Concentrates in acid conditions of parietal cell secretory canaliculi. Forms active sulfenamide metabolite which irreversibly binds to and inactivates hydrogen-potassium ATPase (proton- or acid pump), blocking final step in secretion of hydrochloric acid. Acid secretion inhibited until additional hydrogen-potassium ATPase synthesized, resulting in prolonged duration of action. Suppresses H. pylori in duodenal ulcer and/or reflux esophagitis infected with organism.

Therapeutic use

Active duodenal ulcer disease or active benign gastric ulcer. Heartburn and other symptoms associated with gastroesophageal reflux disease. Endoscopically-diagnosed erosive esophagitis. Maintenance healing of erosive esophagitis. Hypersecretory conditions. As part of multidrug regimen for H. pylori eradication.

Pregnancy and lactiation implications

Crosses placenta. Congenital abnormalities reported following omeprazole use during pregnancy. Should be used during pregnancy only if potential benefit to mother outweighs possible risk to fetus. Enters breast milk (not recommended in nursing women).

Unlabeled use

Healing NSAID-induced ulcers. Prevention of NSAID-induced ulcer. Stress-ulcer prophylaxis in the critically ill.

Contraindications

Hypersensitivity to omeprazole or any component of the formulation.

Warnings and precautions

Long-term omeprazole therapy caused atrophic gastritis (by biopsy). In long-term (2-year) studies in rats, omeprazole produced dose-related increase in gastric carcinoid tumors. Relief of symptoms does not preclude presence of gastric malignancy. Use of proton pump inhibitors may increase risk of GI infection (e.g. Salmonella, Campylobacter). Bioavailability may be increased in hepatic dysfunction. Bioavailability may be increased in patients of Asian descent. Bioavailability may be increased in the elderly. Self-medication use not approved for children <18 years of age.

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