Table of contents

  • Brand Names
  • Chemistry
  • Pharmacologic Category
  • Mechanism of Action
  • Therapeutic Use
  • Pregnancy and Lactation Implications
  • Contraindications
  • Warnings and Precautions
  • Adverse Reactions
  • Genes that may be involved
  • Substrate of
  • Inhibits
  • Drug Interactions
  • Nutrition/Nutraceutical Interactions
  • Dosage
  • Pharmacokinetics and Pharmacodynamics
  • Special Considerations

Brand Names


Belgium: Duraprox; Bulgaria: Dayrun; Czech Republic: Dayrun; Greece: Duraprox, Misaf, Nisaid, Oxapron, Trimelot; Hungary: Flusyd; Italy: Walix; Poland: Medoprozin; Romania: Dayrun; Spain: Duraprox.

North America

Canada: Daypro, Oxaprozin; USA: Daypro, Oxaprozin.


Japan: Allcerozin, Alvo, Amolintan, Daypro, Inamizin, Ocefazine, Okinesujin, Olosaruzin, Oxachilin, Oxyacidon, Papirzin, Salbonat, Xapzin.

Drug combinations


Oxaprozin: C~18~H~15~NO~3~. Mw: 293.32. (1) 2-Oxazolepropanoic acid, 4,5-diphenyl-; (2) 4,5-Diphenyl-2-oxazolepropionic acid. CAS-21256-18-8 (1973).

Pharmacologic Category

Analgesics and Antipyretics; Other Nonsteroidal Anti-inflammatory Agents. (ATC-Code: M01AE12).

Mechanism of action

Reversibly inhibits cyclooxygenase-1 and 2 (COX-1/PTGS1 and COX2/PTGS2) enzymes, which results in decreased formation of prostaglandin precursors. Has antipyretic, analgesic, and anti-inflammatory properties.

Therapeutic use

Management of signs and symptoms of osteoarthritis and rheumatoid arthritis. Juvenile rheumatoid arthritis.

Pregnancy and lactiation implications

Safety and efficacy in pregnant women not established. Exposure late in pregnancy may lead to premature closure of ductus arteriosus and may inhibit uterine contractions. Excretion in breast milk unknown (not recommended in nursing women).

Unlabeled use


Hypersensitivity to oxaprozin, aspirin, other NSAIDs, or any component of the formulation. Perioperative pain in setting of coronary artery bypass graft surgery. Active gastrointestinal bleeding, ulcer disease. Patients with «aspirin triad» (asthma, rhinitis (with or without nasal polyps), and aspirin intolerance); fatal asthmatic and anaphylactoid reactions may occur.

Warnings and precautions

Anaphylactoid reactions may occur (higher risk in «aspirin triad» (bronchial asthma, aspirin intolerance, rhinitis)). Do not use in patients who experience bronchospasm, asthma, rhinitis, or urticaria with NSAID or aspirin therapy. Use caution in other forms of asthma. Platelet adhesion and aggregation may be decreased (prolong bleeding time). Anemia may occur. NSAIDs associated with increased risk of adverse cardiovascular thrombotic events (myocardic infarction, stroke, new onset or worsening of pre-existing hypertension). Use caution with fluid retention, heart failure, or hypertension. Concurrent administration of ibuprofen, and potentially other nonselective NSAIDs, may interfere with the cardioprotective effect of aspirin. NSAIDs may increase risk of gastrointestinal irritation, inflammation, ulceration, bleeding, and perforation (caution if history of gastrointestinal disease, concurrent therapy with aspirin, anticoagulants, and/or corticosteroids, smoking, use of alcohol, and elderly or debilitated patients). When used concomitantly with ≤325 mg of aspirin, higher risk of gastrointestinal complications. May cause mild photosensitivity reactions. NSAIDs may cause serious skin adverse events (exfoliative dermatitis, Stevens-Johnson syndrome, and toxic epidermal necrolysis). Use contraindicated for treatment of perioperative pain in setting of coronary artery bypass graft surgery. Risk of myocardic infarction and stroke may be increased with use following coronary artery bypass graft surgery. Use with caution in decreased hepatic function. Severe hepatic reactions (e.g. fulminant hepatitis, liver failure) occurred with NSAID use, rarely (higher risk if impaired renal function, dehydration, heart failure, liver dysfunction, consumption of diuretics, and ACE inhibitors, and elderly); not recommended for use in advanced renal disease (long-term NSAID use may result in renal papillary necrosis). The elderly are at increased risk for adverse effects (especially peptic ulceration, CNS effects, renal toxicity) from NSAIDs, even at low doses. Withhold prior to surgical or dental procedures. False-positive urine immunoassay screening tests for benzodiazepines reported and may occur several days after discontinuing oxaprozin.



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