Benzodiazepines associated with anterograde amnesia. May cause CNS depression. Paradoxical reactions (hyperactive or aggressive behavior) reported with benzodiazepines, particularly in adolescent/pediatric or psychiatric patients. Use with caution in patients receiving other CNS depressants or psychoactive medication (effects with other sedative drugs or ethanol may be potentiated), and in history of drug abuse or acute alcoholism. Tolerance, psychological and physical dependence may occur with prolonged use. May cause hypotension (caution in cardiovascular or cerebrovascular disease, or in patients who would not tolerate transient decreases in blood pressure). Use with caution in hepatic/renal impairment, in impaired gag reflux, in respiratory disease, in debilitated patients, and in the elderly (benzodiazepines associated with falls and traumatic injury). Some forms contains tartrazine. Does not have analgesic, antidepressant, or antipsychotic properties. Rebound or withdrawal symptoms may occur following abrupt discontinuation or large decreases in dose. Flumazenil may cause withdrawal in patients receiving long-term benzodiazepine therapy.