Table of contents

  • Brand Names
  • Drug Combinations
  • Chemistry
  • Pharmacologic Category
  • Mechanism of Action
  • Therapeutic Use
  • Pregnancy and Lactation Implications
  • Contraindications
  • Warnings and Precautions
  • Adverse Reactions
  • Drug Interactions
  • Dosage
  • Pharmacokinetics and Pharmacodynamics
  • Special Considerations

Brand Names


Austria: Kreon, Pancrin, Panzynorm; Bulgaria: Mezym; Czech Republic: Gastrix, Kreon, Pancreolan, Pangrol, Panzynorm, Panzytrat; Denmark: Kreon; Estonia: Kreon; Finland: Kreon; France: Eurobiol; Germany: Bilipeptal, Enzym-Lefax, Helopan 10.000, Kreon, Lipazym, Mezym, Ozym, Pancrin, Pangrol, Pankreatan, Pankreatin, Pankreon, Panpeptal N, Panpur, Panzynorm, Panzytrat, Unexym; Greece: Panzytrat; Hungary: Dipankrin, Kreon, Mezym, Neo-Panpur, Pangrol, Panzytrat; Ireland: Nutrizym; Latvia: Kreon, Mezym, Pangrol, Panzytrat; Lithuania: Enzystal, Panzytrat; Luxembourg: Hepa-Merz, Panzytrat; Malta: Pancrex V; Netherlands: Panzytrat; Poland: Combizym, Kreon, Lipancrea, Neo-Pancreatinum, Pangrol, Panzytrat; Portugal: Kreon; Romania: Kreon, Mezym, Pangrol; Slovakia: Combizym, Kreon, Pancreolan, Pangrol, Panzynorm, Panzytrat; Slovenia: Kreon; Spain: Digestomen Complex, Kreon; Sweden: Kreon; UK: Nutrizym, Pancrease HL, Pancrex V.

North America

Canada: Azeo-Pangen Pancreatin, Bio-Zyme, Pancreas, Pancreatinum, Pankreas.

Latin America

Argentina: Enzybar, Pancrecura; Brazil: Opti-Free Supraclens, Polyzym; Mexico: Opti-Free.


Japan: Pancreatin.

Drug combinations

Pancreatin and Simethicone

Other Pancreatin combinations: Aspergillus oryzae enzyme mixture; Bromelain; Cellulase Enzyme; Chymotrypsin; Dehydrocholic Acid; Deoxycholic Acid; Diazepam; Dimethylpolysiloxane; Homatropine; Magnesium; Magnesium Bile Salts, Metoclopramide; Mosapride; Papain; Pepsin; Rutoside; Silymarin; Takadiastasa; Thioctic Acid; Trypsin


Pancreatin: CAS-8049-47-6.

Pharmacologic Category

Gastrointestinal Drugs; Digestants. Enzyme. (ATC-Code: H04).

Mechanism of action

An enzyme supplement, containing combination of lipase, amylase and protease. Enhances digestion of proteins, starch and fat in stomach and intestines.

Therapeutic use

Relief of functional indigestion due to enzyme deficiency or imbalance.

Pregnancy and lactiation implications

Use caution during pregnancy or lactation.

Unlabeled use


Hypersensitivity to pork protein or any component of the formulation. Acute pancreatitis or acute exacerbations of chronic pancreatic disease.

Warnings and precautions

Some products made from pork protein and should not be used if allergic to pork.



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