Pancrelipase
- Atc Codes:H04
- CAS Codes:53608-75-6
- PHARMGKB ID:53608-75-6
Table of contents
- Brand Names
- Drug Combinations
- Chemistry
- Pharmacologic Category
- Mechanism of Action
- Therapeutic Use
- Unlabeled Use
- Pregnancy and Lactation Implications
- Contraindications
- Warnings and Precautions
- Adverse Reactions
- Drug Interactions
- Nutrition/Nutraceutical Interactions
- Dosage
- Pharmacokinetics and Pharmacodynamics
- Special Considerations
Brand Names
Europe
Belgium: Creon; Denmark: Creon, Pancrease; France: Creon; Germany: Cotazym; Greece: Creon; Ireland: Creon; Italy: Creon, Pancrex; Luxembourg: Creon; Malta: Creon; Netherlands: Creon, Pancrease; Sweden: Creon; UK: Creon.
North America
USA: Creon, Pancreaze, Zenpep.
Latin America
Argentina: Creon; Brazil: Cotazym, Creon, Dasc; Mexico: Creon, Pancrease.
Drug combinations
Pancrelipase: Cyanocobalamin (Vitamin B~12~); Cysteine; Riboflavin (Vitamin B~2~)
Chemistry
Pancrelipase: A concentrate of pancreatic enzymes standardized for lipase content. (1) Lipase, triacylglycerol; (2) Lipase of pancreas. CAS-53608-75-6 (1963).
Pharmacologic Category
Gastrointestinal Drugs; Digestants. Enzyme. (ATC-Code: H04).
Mechanism of action
Contains combination of lipase, amylase, and protease. Products formulated to dissolve in more basic pH of duodenum so they may act locally to break down fats, protein, and starch.
Therapeutic use
Replacement therapy in symptomatic treatment of malabsorption syndrome caused by pancreatic insufficiency.
Pregnancy and lactiation implications
Use caution during pregnancy or lactation.
Unlabeled use
Treatment of occluded feeding tubes.
Contraindications
Hypersensitivity to pork protein or any component of the formulation. Acute pancreatitis or acute exacerbations of chronic pancreatic disease.
Warnings and precautions
Fibrotic strictures in colon (some requiring surgery) reported with high doses; use caution, especially in children with cystic fibrosis. Pancrelipase inactivated by acids. Avoid inhalation of powder (may cause nasal and respiratory tract irritation).