Pentosan Polysulfate Sodium
- Atc Codes:C05BA04
- CAS Codes:140207-93-8
- PHARMGKB ID:140207-93-8
Table of contents
- Brand Names
- Chemistry
- Pharmacologic Category
- Mechanism of Action
- Therapeutic Use
- Pregnancy and Lactation Implications
- Contraindications
- Warnings and Precautions
- Adverse Reactions
- Genes that may be involved
- Drug Interactions
- Dosage
- Pharmacokinetics and Pharmacodynamics
Brand Names
Europe
Austria: Polyanion; France: Hemoclar; Germany: Fibrezym, Pentosanpolysulfat SP 54, Thrombocid; Hungary: SP54; Italy: Fibrase; Portugal: Fibrocide, Thrombocid; Spain: Fibrocid, Thrombocid.
North America
Canada: Elmiron; USA: Elmiron.
Latin America
Argentina: Elmiron.
Drug combinations
Chemistry
Pentosan Polysulfate Sodium: [C~5~H~6~Na~2~O~10~S~2~]~n~ (n=6 to 12). (1) 4-O-Methyl-α-D-glucurono-β-D-xylan, hydrogen sulfate, sodium salt; (2)(4-O-Methyl-α-D-glucurono)-(1→2)-(1→4)-β-D-xylopyranan, hydrogen sulfate, sodium salt. CAS-140207-93-8 (1988).
Pharmacologic Category
Analgesics and Antipyretics, Miscellaneous. Urinary Analgesic. (ATC-Code: C05BA04).
Mechanism of action
Drug appears to adhere to bladder wall mucosa where it may act as buffer to protect tissues from irritating substances in urine.
Therapeutic use
Relief of bladder pain or discomfort due to interstitial cystitis (Orphan drug).
Pregnancy and lactiation implications
There are no adequate, well-controlled studies in pregnant women. Use with caution and only if clearly needed during pregnancy. Excretion in breast milk unknown (use caution).
Unlabeled use
Contraindications
Hypersensitivity to pentosan polysulfate sodium, related compounds (LMWHs or heparin), or any component of the formulation.
Warnings and precautions
Bleeding complications such as ecchymosis, epistaxis and gum bleeding, may occur. Evaluated patients with aneurysm, hemophilia and/or thrombocytopenia, or gastrointestinal ulcerations, polyps, and/or diverticula before initiating therapy. Use with caution in history of heparin-induced thrombocytopenia, and in hepatic impairment.