May cause CNS depression. May cause hypotension, particularly when administered intravenously (use with caution in hemodynamically unstable patients (hypotension or shock)). May cause paradoxical responses, including agitation and hyperactivity, particularly in acute pain and pediatric patients. May cause respiratory depression, particularly when administered intravenously (use with caution in respiratory disease). Use with caution in depression or suicidal tendencies, in hepatic or renal impairment, and in hypoadrenalism. Potential for drug dependency exists (use with caution in history of drug abuse). Tolerance, psychological and physical dependence may occur with prolonged use. Effects with other sedative drugs or ethanol may be potentiated. Use with caution in debilitated patients, in the elderly (not recommended as a sedative), in children (associated with cognitive deficits). Intra-arterial administration may cause reactions ranging from transient pain to gangrene, and is contraindicated. Subcutaneous administration may cause tissue irritation (e.g. redness, tenderness, necrosis); not recommended. Should not be administered in acute pain. Anticonvulsants should not be discontinued abruptly. Injectable solutions contain propylene glycol.