Phytonadione (Vitamin K1)
- Atc Codes:B02BA01
- CAS Codes:84-80-0
- PHARMGKB ID:84-80-0
Table of contents
- Brand Names
- Drug Combinations
- Chemistry
- Pharmacologic Category
- Mechanism of Action
- Therapeutic Use
- Unlabeled Use
- Pregnancy and Lactation Implications
- Contraindications
- Warnings and Precautions
- Adverse Reactions
- Caution and personalized dose adjustment in patients with the following genotypes
- Other genes that may be involved
- Drug Interactions
- Dosage
- Pharmacokinetics and Pharmacodynamics
- Special Considerations
Brand Names
Europe
Austria: Konakion; Belgium: Konakion, Vitamon K; Bulgaria: Konakion; Cyprus: Haemokion, Konakion; Czech Republic: Kanavit; Denmark: Konakion; Finland: Konakion; France: Vitamine K1; Germany: Ka-Vit, Konakion; Greece: Konakion, Vitamine K1; Hungary: Konakion; Ireland: Konakion; Italy: Konakion; Luxembourg: Konakion; Netherlands: Konakion; Poland: Vitacon; Portugal: Kanakion; Romania: Fitomenadion; Slovakia: Kanavit; Slovenia: Konakion; Spain: Konakion; Sweden: Konakion; UK: Konakion, Phytonadione, Vitamin K1.
North America
Canada: Vitamin K1; USA: Mephyton, Phyonadione, Vitamin K1.
Latin America
Argentina: K1 Topic, Konakion, Rupek, Vitamina K1; Brazil: Kanakion, Kavit, Vikatrón, Vita K; Mexico: Dionadión, Fitomenadiona.
Asia
Japan: Kativ, Kaywan, Univitan K1, Vitamin K1.
Drug combinations
Phytonadione: Ascorbic Acid (Vitamin C); Beta Carotene; Biotin (Vitamin B~7~); Calcium; Canola Oil; Carnitine; Carob Gum; Cholecalciferol (Vitamin D~3~); Cholesterol; Coconut Oil; Choline; Copper; Corn Oil; Cyanocobalamin (Vitamin B~12~); Ergocalciferol (Vitamin D~2~); Folic Acid (Vitamin B~9~); Inositol; Iodine; Iron; Lactose; Linoleic Acid; Linolenic Acid; Magnesium; Manganese; Niacin (Vitamin B~3~); Niacinamide; Palm Oil; Phosphate; Phosphorus; Piridoxine (Vitamin B~6~); Potassium; Retinol (Vitamin A); Riboflavin (Vitamin B~2~); Skim Milk; Sodium; Soluble Lecithin; Sunflower Oil; Taurine; Thiamine (Vitamin B~1~); Tocopherol (Vitamin E~1~); Zinc
Chemistry
Phytonadione: C~31~H~46~O~2~. Mw: 450.70. (1) 1,4-Naphthalenedione, 2-methyl-3-(3,7,11,15-tetramethyl-2-hexadecenyl)-, [R-[R*,R*-(E)]]-; (2) Phylloquinone. CAS-84-80-0.
Pharmacologic Category
Vitamins; Vitamin K Activity. Antidotes. (ATC-Code: B02BA01).
Mechanism of action
Promotes liver synthesis of clotting factors (II, VII, IX, X); however, exact mechanism of this stimulation unknown.
Therapeutic use
Prevention and treatment of hypoprothrombinemia caused by coumarin derivative-induced or other drug-induced vitamin K deficiency, hypoprothrombinemia caused by malabsorption or inability to synthesize vitamin K. Hemorrhagic disease of newborn.
Pregnancy and lactiation implications
Use caution during pregnancy or lactation.
Unlabeled use
Treatment of hypoprothrombinemia caused by anticoagulant rodenticides.
Contraindications
Hypersensitivity to phytonadione or any component of the formulation.
Warnings and precautions
Severe reactions resembling hypersensitivity (e.g. anaphylaxis) reactions occurred rarely during or immediately after I.V. administration (even with proper dilution and rate of administration). Allergic reactions also occurred with I.M. and SubQ injections. Ineffective in hereditary hypoprothrombinemia. Use with caution in renal impairment (including premature infants), and in newborns, especially premature infants (hemolysis, jaundice, and hyperbilirubinemia reported with larger than recommended doses). Injectable products may contain aluminum (may result in toxic levels following prolonged administration). Some dosage forms contain benzyl alcohol («gasping syndrome» in neonates).