Pinaverium
- Atc Codes:A03AX04
- CAS Codes:53251-94-8#59995-65-2
- PHARMGKB ID:53251-94-8#59995-65-2
Table of contents
- Brand Names
- Chemistry
- Pharmacologic Category
- Mechanism of Action
- Therapeutic Use
- Pregnancy and Lactation Implications
- Contraindications
- Warnings and Precautions
- Adverse Reactions
- Drug Interactions
- Dosage
- Special Considerations
Brand Names
Europe
Bulgaria: Dicetel; France: Dicetel, Pinaverium; Greece: Bacin, Dicetel; Hungary: Dicetel; Italy: Dicetel; Lithuania: Dicetel; Luxembourg: Dicetel; Portugal: Dicetel; Slovakia: Dicetel; Spain: Eldicet.
North America
Canada: Dicetel.
Latin America
Argentina: Dicetel, Nulite; Brazil: Dicetel; Mexico: Dicetel, Distental, Diver, Lutropen, Pakab, Zerpyco.
Drug combinations
Chemistry
Pinaverium Bromide: C~26~H~41~Br~2~NO~4~. Mw: 591.42. 4-(6-Bromoveratryl)-4-[2-[2-(6,6-dimethyl-2-norpinyl)ethoxy]ethyl]morpholinium bromide. CAS-53251-94-8; CAS-59995-65-2 (pinaverium).
Pharmacologic Category
GI Drugs, Miscellaneous; Calcium Channel Blocker. (ATC-Code: A03AX04).
Mechanism of action
Blocks influx of calcium via voltage-sensitive channels within smooth muscle cells of GI tract.
Therapeutic use
Treatment and relief of symptoms associated with irritable bowel syndrome. Treatment of symptoms related to functional disorders of biliary tract.
Pregnancy and lactiation implications
There are no adequate, well-controlled studies in pregnant women. Use not recommended in pregnant or nursing women.
Unlabeled use
Contraindications
Hypersensitivity to pinaverium or any component of the formulation.
Warnings and precautions
Increased angina and/or MI occurred with initiation or dosage titration of calcium channel blockers. May cause esophageal irritation (avoid use in possible gastroesophageal reflux or hiatal hernia). Symptomatic hypotension with or without syncope can rarely occur. Most common side-effect is peripheral edema. Reflex tachycardia might occur. Avoid use as treatment for GI motility dysfunction associated with underlying disease states. Use with caution in hepatic impairment, and in idiopathic hypertrophic subaortic stenosis.