Hazardous agent. Inflammatory responses within treatment area may result in substernal chest pain. Ocular discomfort reported. Photosensitivity reactions common in patients exposed to direct sunlight or bright indoor light (e.g. fluorescent lights, unshaded light bulbs, examination/operating lights). Esophageal strictures are common adverse events associated with photodynamic therapy of Barrett’s esophagus. Fistula formation may occur after resolution of tumors with deep bronchial wall invasion. Generally not suited for treatment of esophageal or gastric varices (caution if used at all). Porfimer treatment for tumors which erode into trachea or bronchial tree likely to cause fistula (use not recommended). Use contraindicated in existing tracheoesophageal or bronchoesophageal fistula. Elimination may be prolonged in hepatic or renal impairment (toxicities may be increased). Photosensitivity may be increased beyond 90 days in mild-to-severe hepatic impairment or severe renal impairment. Concurrent use with other photosensitizing agents may increase risk for photosensitivity reactions. Avoid extravasation.