Hyperkalemia may present as tall peaked symmetrical T waves. S-T elevation may present in severe hyperkalemia. Severe hyperkalemia may lead to muscle weakness/paralysis and cardiac conduction abnormalities (e.g. heart block, ventricular arrhythmias, asystole). Hypokalemia is highly arrhythmogenic, particularly in setting of ischemia or digitalis toxicity (appears as flattening of T wave; U waves may appear). Use with caution in cardiovascular disease (e.g. heart failure, cardiac arrhythmias). Changes in serum potassium concentrations can occur during acid/base correction (use with caution in acid/base alterations). Use with caution in disorders or conditions likely to contribute to altered serum potassium and hyperkalemia (e.g. untreated Addison’s disease, heat cramps, severe tissue breakdown from trauma or burns), and in renal impairment. Contraindicated with severe impairment. Use with caution in digitalized patients (may be more susceptible to potentially life-threatening cardiac effects with rapid changes in serum potassium concentrations); also in patients receiving concomitant medications or therapies which increase potassium (e.g. ACEIs, potassium-sparing diuretics, potassium-containing salt substitutes). Solution for injection contains aluminum (use with caution in impaired renal function and in premature infants). Use extreme caution with parenteral administration (inappropriate parenteral administration may be fatal). Always administer potassium further diluted. Pain and phlebitis may occur during parenteral infusion.