Severe hyperkalemia may lead to muscle weakness/paralysis and cardiac conduction abnormalities (e.g. heart block, ventricular arrhythmias, asystole). Changes in serum potassium concentrations can occur during acid/base correction (use with caution in acid/base alterations). Patients may be more susceptible to life-threatening cardiac effects associated with hyper-/hypokalemia (use with caution in cardiovascular disease (e.g. heart failure, cardiac arrhythmias)). Use with caution in disorders or conditions likely to contribute to altered serum potassium and hyperkalemia (e.g. untreated Addison’s disease, heat cramps, severe tissue breakdown from trauma or burns). Use with caution in renal impairment (contraindicated with severe impairment), in digitalized patients (may be more susceptible to potentially life-threatening cardiac effects with rapid changes in serum potassium concentrations), and in patients receiving concomitant medications or therapies which increase potassium (e.g. ACEI, potassium-sparing diuretics, potassium-containing salt substitutes). Oral liquid preparations (not solid) should be used in esophageal compression or delayed gastric emptying. Use extreme caution with parenteral administration (pain and phlebitis may occur; inappropriate parenteral administration may be fatal). Should be administered further diluted (avoid administering potassium diluted in dextrose solutions during initial therapy). Potential for transient decreases in serum potassium due to intracellular shift of potassium from dextrose-stimulated insulin release.