Severe hyperkalemia may lead to muscle weakness/paralysis and cardiac conduction abnormalities (e.g. heart block, ventricular arrhythmias, asystole). Changes in serum potassium concentrations can occur during acid/base correction (use with caution in acid/base alterations). Patients may be more susceptible to life-threatening cardiac effects associated with hyper-/hypokalemia (use with caution in cardiovascular disease (e.g. heart failure, cardiac arrhythmias)). Use with caution in renal impairment, in digitalized patients (may be more susceptible to potentially life-threatening cardiac effects with rapid changes in serum potassium concentrations), and in patients receiving concomitant medications or therapies which increase potassium (e.g. ACEI, potassium-sparing diuretics, potassium-containing salt substitutes). Oral liquid preparations (not solid) should be used in esophageal compression or delayed gastric emptying. Admixture of phosphate and calcium in I.V. fluids can result in calcium phosphate precipitation. Use extreme caution when administering potassium phosphate parenterally (may cause pain and phlebitis).