Table of contents

  • Brand Names
  • Drug Combinations
  • Chemistry
  • Pharmacologic Category
  • Mechanism of Action
  • Therapeutic Use
  • Adverse Reactions
  • Drug Interactions
  • Dosage

Brand Names


France: Tronothane; Italy: Tronotene; Spain: Balsabit, Denutraxán.

North America

Canada: Dermoplast Poison.

Drug combinations

Pramoxine and Chlorhexidine Gluconate

Pramoxine and Hydrocortisone

Pramoxine, Chlorhexidine Gluconate, and Zinc Oxide

Pramoxine, Bacitracin, Neomycin, and Polymyxin B


Pramoxine Hydrochloride: C~17~H~27~NO~3~ HCl. Mw: 329.86. (1) Morpholine, 4-[3-(4-butoxyphenoxy)propyl]-, hydrochloride; (2) 4-[3-(p-Butoxyphenoxy)propyl]morpholine hydrochloride. CAS-637-58-1; CAS-140-65-8 (pramoxine).

Pharmacologic Category

Skin and Mucous Membrane Agents; Antipruritics and Local Anesthetics. (ATC-Code: C05AD).

Mechanism of action

Decreases permeability of neuronal membrane to sodium ions. Both initiation and conduction of nerve impulses are blocked, thus depolarization of neuron is inhibited.

Therapeutic use

Temporary relief of pain and itching associated with anogenital pruritus or irritation. Dermatosis, minor burns, or hemorrhoids.

Pregnancy and lactiation implications

Unlabeled use


Warnings and precautions



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