Pramoxine
- Atc Codes:C05AD
- CAS Codes:637-58-1#140-65-8
- PHARMGKB ID:637-58-1#140-65-8
Table of contents
- Brand Names
- Drug Combinations
- Chemistry
- Pharmacologic Category
- Mechanism of Action
- Therapeutic Use
- Adverse Reactions
- Drug Interactions
- Dosage
Brand Names
Europe
France: Tronothane; Italy: Tronotene; Spain: Balsabit, Denutraxán.
North America
Canada: Dermoplast Poison.
Drug combinations
Pramoxine and Chlorhexidine Gluconate
Pramoxine and Hydrocortisone
Pramoxine, Chlorhexidine Gluconate, and Zinc Oxide
Pramoxine, Bacitracin, Neomycin, and Polymyxin B
Chemistry
Pramoxine Hydrochloride: C~17~H~27~NO~3~ HCl. Mw: 329.86. (1) Morpholine, 4-[3-(4-butoxyphenoxy)propyl]-, hydrochloride; (2) 4-[3-(p-Butoxyphenoxy)propyl]morpholine hydrochloride. CAS-637-58-1; CAS-140-65-8 (pramoxine).
Pharmacologic Category
Skin and Mucous Membrane Agents; Antipruritics and Local Anesthetics. (ATC-Code: C05AD).
Mechanism of action
Decreases permeability of neuronal membrane to sodium ions. Both initiation and conduction of nerve impulses are blocked, thus depolarization of neuron is inhibited.
Therapeutic use
Temporary relief of pain and itching associated with anogenital pruritus or irritation. Dermatosis, minor burns, or hemorrhoids.