Angioedema reported, may be life-threatening (use with caution in history of angioedema episodes). Concurrent use with other drugs known to cause angioedema (e.g. ACEIs) may increase risk. May cause CNS depression. Hypersensitivity reactions, including skin redness, blistering, hives, rash, dyspnea, and wheezing reported. May decrease platelet count. May cause mild prolongation of PR interval (use with caution in underlying AV block). Associated with increases in CPK and rare cases of rhabdomyolysis. Visual disturbances, such as blurred vision, decreased acuity and visual field changes, associated with therapy. Use may be associated with weight gain and peripheral edema (effect on weight gain/edema may be additive to thiazolidinedione antidiabetic agent particularly in prior cardiovascular disease). Use with caution in CHF, hypertension, or diabetes (weight gain and/or peripheral edema may occur). Use with caution in renal impairment. Effects with other sedative drugs or ethanol may be potentiated. Increased incidence of hemangiosarcoma noted in animal studies (unknown significance in humans). Therapy should be withdrawn gradually.