Probenecid

Table of contents

  • Brand Names
  • Drug Combinations
  • Chemistry
  • Pharmacologic Category
  • Mechanism of Action
  • Therapeutic Use
  • Pregnancy and Lactation Implications
  • Contraindications
  • Warnings and Precautions
  • Adverse Reactions
  • Genes that may be involved
  • Inhibits
  • Drug Interactions
  • Dosage
  • Pharmacokinetics and Pharmacodynamics
  • Special Considerations

Brand Names

Europe

Denmark: Probenecid; France: Benemide; Germany: Probenecid; Greece: Benemid, Probenecid, Statpack; Sweden: Probecid.

North America

Canada: Benuryl; USA: Probalan, Probenecid.

Latin America

Mexico: Benecid.

Asia

Japan: Benecid.

Drug combinations

Probenecid and Colchicine

Chemistry

Probenecid: C~13~H~19~NO~4~S. Mw: 285.36. (1) Benzoic acid, 4-[(dipropylamino)sulfonyl]-; (2) p-(Dipropylsulfamoyl)benzoic acid. CAS-57-66-9.

Pharmacologic Category

Uricosuric Agents. Antigout Agents. (ATC-Code: M04AB01).

Mechanism of action

Competitively inhibits reabsorption of uric acid at proximal convoluted tubule, thereby promoting its excretion and reducing serum uric acid levels. Increases plasma levels of weak organic acids (penicillins, cephalosporins, or other β-lactam antibiotics) by competitively inhibiting their renal tubular secretion.

Therapeutic use

Prevention of hyperuricemia associated with gout or gouty arthritis. Prolongation and elevation of β-lactam plasma levels.

Pregnancy and lactiation implications

Caution during lactation.

Unlabeled use

Contraindications

Hypersensitivity to probenecid or any component of the formulation. High-dose aspirin therapy. Blood dyscrasias. Uric acid kidney stones. Children <2 years of age.

Warnings and precautions

May cause exacerbation of acute gouty attack (avoid fluctuation in uric acid (increase or decrease)). Use with caution in peptic ulcer disease. Monotherapy may not be effective in creatinine clearance <30 mL/minute. Use of probenecid with penicillin in renal insufficiency not recommended. Salicylates may diminish therapeutic effect of probenecid. May rarely cause leukopenia (use caution with clozapine and carbamazepine).

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