Protamine Sulfate

Table of contents

  • Brand Names
  • Chemistry
  • Pharmacologic Category
  • Mechanism of Action
  • Therapeutic Use
  • Unlabeled Use
  • Pregnancy and Lactation Implications
  • Contraindications
  • Warnings and Precautions
  • Adverse Reactions
  • Dosage
  • Special Considerations

Brand Names


Austria: Protaminsulfat; Belgium: Protamine Sulfaat; Denmark: Protaminsulfat; Estonia: Protamine Sulphate; Finland: Protamiinisulfaatti; France: Protamine Choay; Germany: Protaminsulfat; Greece: Protamine Sulfate; Hungary: Protamin; Ireland: Protamine Sulphate; Italy: Protamina Solfato; Lithuania: Protamine Sulphate; Luxembourg: Protamine Sulfaat; Netherlands: Protamine Sulfaat; Poland: Protaminum; Portugal: Sulfato de Protamina; Romania: Protamine Sulphate; Slovenia: Protaminijev Sulfat; Spain: Protamina; Sweden: Protaminsulfat; UK: Prosulf, Protamine Sulphate.

North America

Canada: Protamine Sulfate; USA: Protamine Sulfate.

Latin America

Argentina: Denpru, Protamina; Brazil: Protamina; Mexico: Protamina.


Japan: Protamine Sulfate.

Drug combinations


Protamine Sulfate: CAS-9009-65-8.

Pharmacologic Category

Antihemorrhagic Agents; Antiheparin Agents. Antidotes. (ATC-Code: V03AB14).

Mechanism of action

Combines with strongly acidic heparin to form stable complex (salt) neutralizing anticoagulant activity of both drugs.

Therapeutic use

Treatment of heparin overdosage. Neutralization of heparin during surgery or dialysis procedures.

Pregnancy and lactiation implications

Caution during pregnancy or lactation.

Unlabeled use

Treatment of low molecular weight heparin overdose.


Hypersensitivity to protamine or any component of the formulation.

Warnings and precautions

Heparin rebound associated with anticoagulation and bleeding reported to occur occasionally. May cause hypersensitivity reaction. Hypotension, cardiovascular collapse, noncardiogenic pulmonary edema, pulmonary vasoconstriction, and pulmonary hypertension may occur (risk factors include use of high doses or overdose, repeated doses, previous protamine administration (including protamine-containing drugs), fish allergy, vasectomy, severe left ventricular dysfunction, and abnormal preoperative pulmonary hemodynamics). Too rapid administration can cause severe hypotensive and anaphylactoid-like reactions. May be ineffective in some patients following cardiac surgery.



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