Protamine Sulfate
- Atc Codes:V03AB14
- CAS Codes:9009-65-8
- PHARMGKB ID:9009-65-8
Table of contents
- Brand Names
- Chemistry
- Pharmacologic Category
- Mechanism of Action
- Therapeutic Use
- Unlabeled Use
- Pregnancy and Lactation Implications
- Contraindications
- Warnings and Precautions
- Adverse Reactions
- Dosage
- Special Considerations
Brand Names
Europe
Austria: Protaminsulfat; Belgium: Protamine Sulfaat; Denmark: Protaminsulfat; Estonia: Protamine Sulphate; Finland: Protamiinisulfaatti; France: Protamine Choay; Germany: Protaminsulfat; Greece: Protamine Sulfate; Hungary: Protamin; Ireland: Protamine Sulphate; Italy: Protamina Solfato; Lithuania: Protamine Sulphate; Luxembourg: Protamine Sulfaat; Netherlands: Protamine Sulfaat; Poland: Protaminum; Portugal: Sulfato de Protamina; Romania: Protamine Sulphate; Slovenia: Protaminijev Sulfat; Spain: Protamina; Sweden: Protaminsulfat; UK: Prosulf, Protamine Sulphate.
North America
Canada: Protamine Sulfate; USA: Protamine Sulfate.
Latin America
Argentina: Denpru, Protamina; Brazil: Protamina; Mexico: Protamina.
Asia
Japan: Protamine Sulfate.
Drug combinations
Chemistry
Protamine Sulfate: CAS-9009-65-8.
Pharmacologic Category
Antihemorrhagic Agents; Antiheparin Agents. Antidotes. (ATC-Code: V03AB14).
Mechanism of action
Combines with strongly acidic heparin to form stable complex (salt) neutralizing anticoagulant activity of both drugs.
Therapeutic use
Treatment of heparin overdosage. Neutralization of heparin during surgery or dialysis procedures.
Pregnancy and lactiation implications
Caution during pregnancy or lactation.
Unlabeled use
Treatment of low molecular weight heparin overdose.
Contraindications
Hypersensitivity to protamine or any component of the formulation.
Warnings and precautions
Heparin rebound associated with anticoagulation and bleeding reported to occur occasionally. May cause hypersensitivity reaction. Hypotension, cardiovascular collapse, noncardiogenic pulmonary edema, pulmonary vasoconstriction, and pulmonary hypertension may occur (risk factors include use of high doses or overdose, repeated doses, previous protamine administration (including protamine-containing drugs), fish allergy, vasectomy, severe left ventricular dysfunction, and abnormal preoperative pulmonary hemodynamics). Too rapid administration can cause severe hypotensive and anaphylactoid-like reactions. May be ineffective in some patients following cardiac surgery.