Protirelin
- Atc Codes:V04CJ02
- CAS Codes:24305-27-9
- PHARMGKB ID:24305-27-9
Table of contents
- Brand Names
- Chemistry
- Pharmacologic Category
- Mechanism of Action
- Therapeutic Use
- Contraindications
- Adverse Reactions
- Genes that may be involved
- Drug Interactions
- Dosage
- Pharmacokinetics and Pharmacodynamics
Brand Names
Europe
Austria: Antepan; Germany: Antepan, TRH; Greece: TRH; Italy: Irtonin; Luxembourg: TRH; Netherlands: Relefact TRH; Poland: TRH; Spain: TRH; UK: Protirelin.
North America
Canada: Relefact TRH.
Asia
Japan: Alhiruto, Bognin, Hirlok, Hirtonin, Hishidarin, Oriston.
Drug combinations
Chemistry
Protirelin: C~16~H~22~N~6~O~4~. Mw: 362.38. (1) L-Prolinamide, 5-oxo-L-prolyl-L-histidyl-; (2) 5-Oxo-L-prolyl-L-histidyl-L-prolinamide. CAS-24305-27-9 (1974).
Pharmacologic Category
Diagnostic Agent; Pituitary Function. (ATC-Code: V04CJ02).
Mechanism of action
Increases release of thyroid-stimulating hormone from anterior pituitary.
Therapeutic use
Adjunct in diagnostic assessment of thyroid function, and adjunct to other diagnostic procedures in pituitary or hypothalamic dysfunction. Also causes release of prolactin from pituitary and is used to detect defective control of prolactin secretion.
Pregnancy and lactiation implications
Unlabeled use
Contraindications
Hypersensitivity to protirelin additives or any component of the formulation.