Table of contents

  • Brand Names
  • Drug Combinations
  • Chemistry
  • Pharmacologic Category
  • Mechanism of Action
  • Therapeutic Use
  • Pregnancy and Lactation Implications
  • Contraindications
  • Warnings and Precautions
  • Adverse Reactions
  • Genes that may be involved
  • Drug Interactions
  • Nutrition/Nutraceutical Interactions
  • Dosage
  • Pharmacokinetics and Pharmacodynamics
  • Special Considerations

Brand Names


Belgium: Otrivine Nasa-Tab, Rinomar, Vasocedine; Bulgaria: Coldrex Sinus Extend; France: Ephedroides, Sudafed; Ireland: Decongestant, Sudafed; Italy: Sudafed; Luxembourg: Nasa, Soludril Rhinites; Poland: Contac, Sudafed; Portugal: Contact, Sudafed; Spain: Durasina, Pseudoefedrina; UK: Boots Decongestant, Contac, Sudafed.

North America

Canada: Decon, Drixoral ND Long, Pseudoephedrine; USA: Sudafed.

Drug combinations

Pseudoephedrine and Acetaminophen

Pseudoephedrine and Acrivastine

Pseudoephedrine and Brompheniramine

Pseudoephedrine and Carbetapentane

Pseudoephedrine and Carbinoxamine

Pseudoephedrine and Cetirizine

Pseudoephedrine and Chlorpheniramine

Pseudoephedrine and Codeine

Pseudoephedrine and Desloratadine

Pseudoephedrine and Dexbrompheniramine

Pseudoephedrine and Dexchlorpheniramine

Pseudoephedrine and Dextromethorphan

Pseudoephedrine and Diphenhydramine

Pseudoephedrine and Diphenylpyraline

Pseudoephedrine and Ebastine

Pseudoephedrine and Fexofenadine

Pseudoephedrine and Guaifenesin

Pseudoephedrine and Hydrocodone

Pseudoephedrine and Ibuprofen

Pseudoephedrine and Loratadine

Pseudoephedrine and Methscopolamine

Pseudoephedrine and Naproxen

Pseudoephedrine and Triprolidine

Pseudoephedrine, Acetaminophen, and Bromhexine

Pseudoephedrine, Acetaminophen, and Chlorpheniramine

Pseudoephedrine, Acetaminophen, and Clemastine

Pseudoephedrine, Acetaminophen, and Dexbrompheniramine

Pseudoephedrine, Acetaminophen, and Diphenhydramine

Pseudoephedrine, Acetaminophen, and Loratadine

Pseudoephedrine, Acetaminophen, and Pholcodine

Pseudoephedrine, Acetaminophen, and Triprolidine

Pseudoephedrine, Brompheniramine, and Dextromethorphan

Pseudoephedrine, Carbinoxamine, and Hydrocodone

Pseudoephedrine, Chlorpheniramine, and Codeine

Pseudoephedrine, Chlorpheniramine, and Dextromethorphan

Pseudoephedrine, Chlorpheniramine, and Dihydrocodeine

Pseudoephedrine, Chlorpheniramine, and Hydrocodone

Pseudoephedrine, Chlorpheniramine, and Ibuprofen

Pseudoephedrine, Chlorpheniramine, and Methscopolamine

Pseudoephedrine, Codeine, and Guaifenesin

Pseudoephedrine, Codeine, and Triprolidine

Pseudoephedrine, Dextromethorphan, and Guaifenesin

Pseudoephedrine, Dextromethorphan, and Triprolidine

Pseudoephedrine, Dihydrocodeine, and Guaifenesin

Pseudoephedrine, Guaifenesin, and Hydrocodone

Pseudoephedrine, Acetaminophen, Ascorbic Acid (Vitamin C), and Dexbrompheniramine

Pseudoephedrine, Acetaminophen, Bromhexine, and Chlorpheniramine

Pseudoephedrine, Acetaminophen, Bromhexine, and Loratadine

Pseudoephedrine, Acetaminophen, Butetamate, and Chlorpheniramine

Pseudoephedrine, Acetaminophen, Chlorpheniramine, and Dextromethorphan

Pseudoephedrine, Acetaminophen, Dextromethorphan, and Doxylamine

Pseudoephedrine, Acetaminophen, Dextromethorphan, and Guaifenesin


Pseudoephedrine Hydrochloride: C~10~H~15~NO HCl. Mw: 201.69. Benzenemethanol, α-[1-(methylamino)ethyl]-, [S-(R*,R*)]-, hydrochloride; (2)(+)-Pseudoephedrine hydrochloride. CAS-345-78-8; CAS-90-82-4 (pseudoephedrine)(1963).

Pseudoephedrine Sulfate: (C~10~H~15~NO)~2~ H~2~SO~4~. Mw: 428.54. (1) Benzenemethanol, α-[1-(methylamino)ethyl]-, [S-(R*,R*)]-, sulfate (2:1). CAS-7460-12-0 (1978).

Pharmacologic Category

Sympathomimetic (Adrenergic) Agents; α- and β-Adrenergic Agonists. (ATC-Code: R01BA02).

Mechanism of action

Directly stimulates α-adrenergic receptors of respiratory mucosa causing vasoconstriction. Directly stimulates β-adrenergic receptors causing bronchial relaxation, increased heart rate and contractility.

Therapeutic use

Temporary symptomatic relief of nasal congestion due to common cold, upper respiratory allergies, sinusitis. Also promotes nasal or sinus drainage.

Pregnancy and lactiation implications

Use during the 1^st^ trimester may be associated with possible risk of gastroschisis, small intestinal atresia, and hemifacial microsomia due to vasoconstrictive effects of pseudoephedrine. Pseudoephedrine excreted in breast milk.

Unlabeled use


Hypersensitivity to pseudoephedrine or any component of the formulation. With or within 14 days of MAOI therapy. Newborns. Breast-feeding.

Warnings and precautions

Use with caution in cardiovascular disease (including hypertension and ischemic heart disease), diabetes mellitus, increased intraocular pressure or angle-closure glaucoma, prostatic hyperplasia and/or genitourinary obstruction, renal impairment, thyroid dysfunction, and in the elderly (may be more sensitive to adverse effects). Some products may contain phenylalanine.



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