Pseudoephedrine
- Atc Codes:R01BA02
- CAS Codes:345-78-8#90-82-4#7460-12-0
- PHARMGKB ID:345-78-8#90-82-4#7460-12-0
Table of contents
- Brand Names
- Drug Combinations
- Chemistry
- Pharmacologic Category
- Mechanism of Action
- Therapeutic Use
- Pregnancy and Lactation Implications
- Contraindications
- Warnings and Precautions
- Adverse Reactions
- Genes that may be involved
- Drug Interactions
- Nutrition/Nutraceutical Interactions
- Dosage
- Pharmacokinetics and Pharmacodynamics
- Special Considerations
Brand Names
Europe
Belgium: Otrivine Nasa-Tab, Rinomar, Vasocedine; Bulgaria: Coldrex Sinus Extend; France: Ephedroides, Sudafed; Ireland: Decongestant, Sudafed; Italy: Sudafed; Luxembourg: Nasa, Soludril Rhinites; Poland: Contac, Sudafed; Portugal: Contact, Sudafed; Spain: Durasina, Pseudoefedrina; UK: Boots Decongestant, Contac, Sudafed.
North America
Canada: Decon, Drixoral ND Long, Pseudoephedrine; USA: Sudafed.
Drug combinations
Pseudoephedrine and Acetaminophen
Pseudoephedrine and Acrivastine
Pseudoephedrine and Brompheniramine
Pseudoephedrine and Carbetapentane
Pseudoephedrine and Carbinoxamine
Pseudoephedrine and Cetirizine
Pseudoephedrine and Chlorpheniramine
Pseudoephedrine and Codeine
Pseudoephedrine and Desloratadine
Pseudoephedrine and Dexbrompheniramine
Pseudoephedrine and Dexchlorpheniramine
Pseudoephedrine and Dextromethorphan
Pseudoephedrine and Diphenhydramine
Pseudoephedrine and Diphenylpyraline
Pseudoephedrine and Ebastine
Pseudoephedrine and Fexofenadine
Pseudoephedrine and Guaifenesin
Pseudoephedrine and Hydrocodone
Pseudoephedrine and Ibuprofen
Pseudoephedrine and Loratadine
Pseudoephedrine and Methscopolamine
Pseudoephedrine and Naproxen
Pseudoephedrine and Triprolidine
Pseudoephedrine, Acetaminophen, and Bromhexine
Pseudoephedrine, Acetaminophen, and Chlorpheniramine
Pseudoephedrine, Acetaminophen, and Clemastine
Pseudoephedrine, Acetaminophen, and Dexbrompheniramine
Pseudoephedrine, Acetaminophen, and Diphenhydramine
Pseudoephedrine, Acetaminophen, and Loratadine
Pseudoephedrine, Acetaminophen, and Pholcodine
Pseudoephedrine, Acetaminophen, and Triprolidine
Pseudoephedrine, Brompheniramine, and Dextromethorphan
Pseudoephedrine, Carbinoxamine, and Hydrocodone
Pseudoephedrine, Chlorpheniramine, and Codeine
Pseudoephedrine, Chlorpheniramine, and Dextromethorphan
Pseudoephedrine, Chlorpheniramine, and Dihydrocodeine
Pseudoephedrine, Chlorpheniramine, and Hydrocodone
Pseudoephedrine, Chlorpheniramine, and Ibuprofen
Pseudoephedrine, Chlorpheniramine, and Methscopolamine
Pseudoephedrine, Codeine, and Guaifenesin
Pseudoephedrine, Codeine, and Triprolidine
Pseudoephedrine, Dextromethorphan, and Guaifenesin
Pseudoephedrine, Dextromethorphan, and Triprolidine
Pseudoephedrine, Dihydrocodeine, and Guaifenesin
Pseudoephedrine, Guaifenesin, and Hydrocodone
Pseudoephedrine, Acetaminophen, Ascorbic Acid (Vitamin C), and Dexbrompheniramine
Pseudoephedrine, Acetaminophen, Bromhexine, and Chlorpheniramine
Pseudoephedrine, Acetaminophen, Bromhexine, and Loratadine
Pseudoephedrine, Acetaminophen, Butetamate, and Chlorpheniramine
Pseudoephedrine, Acetaminophen, Chlorpheniramine, and Dextromethorphan
Pseudoephedrine, Acetaminophen, Dextromethorphan, and Doxylamine
Pseudoephedrine, Acetaminophen, Dextromethorphan, and Guaifenesin
Chemistry
Pseudoephedrine Hydrochloride: C~10~H~15~NO HCl. Mw: 201.69. Benzenemethanol, α-[1-(methylamino)ethyl]-, [S-(R*,R*)]-, hydrochloride; (2)(+)-Pseudoephedrine hydrochloride. CAS-345-78-8; CAS-90-82-4 (pseudoephedrine)(1963).
Pseudoephedrine Sulfate: (C~10~H~15~NO)~2~ H~2~SO~4~. Mw: 428.54. (1) Benzenemethanol, α-[1-(methylamino)ethyl]-, [S-(R*,R*)]-, sulfate (2:1). CAS-7460-12-0 (1978).
Pharmacologic Category
Sympathomimetic (Adrenergic) Agents; α- and β-Adrenergic Agonists. (ATC-Code: R01BA02).
Mechanism of action
Directly stimulates α-adrenergic receptors of respiratory mucosa causing vasoconstriction. Directly stimulates β-adrenergic receptors causing bronchial relaxation, increased heart rate and contractility.
Therapeutic use
Temporary symptomatic relief of nasal congestion due to common cold, upper respiratory allergies, sinusitis. Also promotes nasal or sinus drainage.
Pregnancy and lactiation implications
Use during the 1^st^ trimester may be associated with possible risk of gastroschisis, small intestinal atresia, and hemifacial microsomia due to vasoconstrictive effects of pseudoephedrine. Pseudoephedrine excreted in breast milk.
Unlabeled use
Contraindications
Hypersensitivity to pseudoephedrine or any component of the formulation. With or within 14 days of MAOI therapy. Newborns. Breast-feeding.
Warnings and precautions
Use with caution in cardiovascular disease (including hypertension and ischemic heart disease), diabetes mellitus, increased intraocular pressure or angle-closure glaucoma, prostatic hyperplasia and/or genitourinary obstruction, renal impairment, thyroid dysfunction, and in the elderly (may be more sensitive to adverse effects). Some products may contain phenylalanine.