Benzodiazepines associated with anterograde amnesia. May cause CNS depression. Use with caution in patients receiving other CNS depressants or psychoactive medication (effects may be potentiated). Use of hypnotic/sedative agents for sleep associated with hypersensitivity reactions. Paradoxical reactions (hyperactive or aggressive behavior) reported, particularly in adolescent/pediatric or psychiatric patients. Increased risk for hazardous sleep-related activities. Use caution in depression (particularly if suicidal risk exists), in history of drug abuse or acute alcoholism (risk of drug dependency), and in hepatic/renal/respiratory impairment. Use with caution in impaired gag reflux, in debilitated patients, and in the elderly (risk of falls and traumatic injury). Does not have analgesic, antidepressant, or antipsychotic properties. Rebound or withdrawal symptoms may occur following abrupt discontinuation or large decreases in dose. Flumazenil may cause withdrawal in patients receiving long-term benzodiazepine therapy.