Rabies Immune Globulin (Human)

Table of contents

  • Brand Names
  • Pharmacologic Category
  • Mechanism of Action
  • Therapeutic Use
  • Pregnancy and Lactation Implications
  • Contraindications
  • Warnings and Precautions
  • Adverse Reactions
  • Drug Interactions
  • Dosage

Brand Names


Austria: Berirab P; Estonia: Imogam Rabies; France: Imogam Rage; Germany: Berirab, Tollwutglobulin Mérieux P; Latvia: Imogam Rabies; Lithuania: Imogam Rabies; Romania: Berirab P, Favirab; Slovakia: Favirab; Spain: Imogam Rabia; UK: Rabies Immunoglobulin.

North America

Canada: HyperRAB, Imogam Rabies; USA: HyperRAB, Imogam Rabies-HT.

Latin America

Argentina: Imogam Rabia; Mexico: Berirab-P, Kamrab.

Drug combinations


Pharmacologic Category

Serums, Toxoids, and Vaccines; Serums. Immune Globulin. (ATC-Code: J07BG).

Mechanism of action

A solution of globulins dried from plasma or serum of selected adult human donors immunized with rabies vaccine who have developed high titers of rabies antibody. Generally contains 10% to 18% of protein of which not less than 80% is monomeric immunoglobulin G.

Therapeutic use

Part of postexposure prophylaxis of persons with rabies exposure who lack history of pre-exposure or postexposure prophylaxis with rabies vaccine or recently documented neutralizing antibody response to previous rabies vaccination.

Pregnancy and lactiation implications

Pregnancy not a contraindication to postexposure prophylaxis.

Unlabeled use


Repeated doses of rabies immune globulin after active immunization with rabies vaccine is initiated.

Warnings and precautions

Hypersensitivity and anaphylactic reactions can occur. Use with caution in isolated immunoglobulin A deficiency or history of systemic hypersensitivity to human immunoglobulins, and in thrombocytopenia or coagulation disorders. I.M. injections may be contraindicated. Product of human plasma (may potentially contain infectious agents which could transmit disease).



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