Riboflavin (Vitamin B2)
- Atc Codes:A11HA04
- CAS Codes:83-88-5#130-40-5
- PHARMGKB ID:83-88-5#130-40-5
Table of contents
- Brand Names
- Drug Combinations
- Chemistry
- Pharmacologic Category
- Mechanism of Action
- Therapeutic Use
- Pregnancy and Lactation Implications
- Warnings and Precautions
- Caution and personalized dose adjustment in patients with the following genotypes
- Other genes that may be involved
- Substrate of
- Dosage
- Pharmacokinetics and Pharmacodynamics
- Special Considerations
Brand Names
Europe
Belgium: Berivine, Ribon; Bulgaria: Vitamin B~2~; France: Beflavine; Germany: B2-Asmedic, Riboflavin, Vitamin B~2~, Werdo 10; Latvia: Vitamin B~2~; Luxembourg: Berivine, Ribon; Netherlands: Riboflavine; Poland: Vita-B~2~, Vitaminum B~2~; Romania: Sicovit B~2~.
North America
Canada: Riboflavin.
Asia
Japan: Actavin B~2~, Bi-Love, Bisulase, Fadvitan, Hibon, Mitan B~2~, Phosflan, Ribovis.
Drug combinations
Riboflavin: Acidum alpha-liponicum; Acidum cis-aconiticum; Acidum citricum; Acidum DL-malicum; Acidum fumaricum; Acidum silicicum; Acidum succinicum; Adenosinum triphosphoricum; Amylase; Anthrachinonum; Aorta bovis fetalis; Ascorbic Acid (Vitamin C); Atropa bella-donna; Aurum chloratum; Barium oxalsuccinicum; Beta vulgaris spp; Beta-Alanine; Beta-Carotene; Biotin (Vitamin B~7~); Bryonia spp; Caffeine; Calcium Carbonate; Calcium carbonicum Hahnemanni; Calcium Lactate; Calcium Phosphate; Cellulose; Centella asiatica; Cerium chloratum; Cerium oxalicum; Chelidonium majus; Cyproheptadine; Cysteine; Cholecalciferol (Vitamin D~3~); Cholinchlorid; Cinchona pubescens; Citrullus colocynthis; Cobalt Sulfate; Cobaltum chloratum; Cobamamide; Coenzyme A; Coenzyme Q~10~; Colchicum autumnale; Conium maculatum; Copper; Copper Sulfate; Cor bovis fetalis; Corpus cavernosum bovis; Cortex cerebri bovis fetalis; Cuprum sulfuricum; Cyanocobalamin (Vitamin B~12~); Cyproheptadine; Damiana leaves; Dexpanthenol; Diencephalon bovis fetalis; Ergocalciferol (Vitamin D~2~); Ferrous Fumarate; Ferrous Gluconate; Ferrous Sulfate; Fluoride; Folic Acid (Vitamin B~9~); Galium aparine; Gelsemium sempervirens; Ginkgo biloba; Ginseng; Glandula suprarenalis bovis; Glandula thyreoidea bovis; Glandulae vesiculosae bovis; Glycine; Glycocholic Acid; Hawthorn; Hepar bovis; Hepar sulfuris; Hydrastis Canadensis; Hydrochinonum; Inositol; Iodine; Ipriflavone; Iron; Isoleucine; Lactose; L-Arginine; L-Carnitine; L-Citrulline; L-Cysteine; L-Cystine; Leonurus cardiaca; L-Histidine; Lien bovis fetalis; Linoleic Acid; Linolenic Acid; Lipoic Acid; L-Leucine; L-Lysine; L-Triptophan; L-Valine; Lycopodium clavatum; Magnesium; Magnesium carbonicum; Magnesium chloratum; Magnesium oroticum; Magnesium Oxide; Magnesium Sulfate; Manganese; Manganese Sulfate; Manganum phosphoricum; Medulla spinalis cuniculi; Melilotus officinalis; Methionine; Molybdenum; Nadidum; Niacin (Vitamin B~3~); Niacinamide; Pancreas bovis; Pancrelipase; Pantothenic Acid (Vitamin B~5~); Papain; Paullinia cupana; Phenylalanine; Phosphorus; Phytonadione (Vitamin K); Placenta bovis; Podophyllum peltatum; Pollen; Potassium; Potassium Sulfate; Procaine; Prostata bovis; Pulsatilla pratensis; Pyridoxine (Vitamin B~6~); Ren bovis fetalis; Retinol (Vitamin A); Routine; Saccharomyces cerevisiae; Selenium; Serine; Silybum marianum; Sodium; Solidago virgaurea; Soy Lecithin; Spigelia anthelmia; Strychnos nux-vomica; Talc; Taraxacum officinale; Taurine; Testis bovis; Thiamine (Vitamin B~1~); Threonine; Thuja occidentalis; Tocopherol (Vitamin E); Tunica mucosa vesicae urinariae bovis; Vaccinium myrtillus; Valerian root; Vasa bovis fetalis; Veratrum album; Yohimbinum hydrochloricum; Zinc; Zinc Sulfate
Chemistry
Riboflavin: C~17~H~20~N~4~O~6~. Mw: 376.36. (1) 5-Deoxy-5-(7,8-dimethyl-2,4-dioxo-3,4-dihydrobenzo[g]pteridin-10(2H)-yl)-D-ribitol. (2) Riboflavine. CAS-83-88-5.
Riboflavin 5′-Phosphate Sodium: C~17~H~20~N~4~NaO~9~P 2H~2~O. Mw: 514.36. Riboflavin 5′-(dihydrogen phosphate), monosodium salt, dihydrate. CAS-130-40-5 (anhydrous).
Pharmacologic Category
Vitamins; Vitamin B Complex. (ATC-Code: A11HA04).
Mechanism of action
Component of flavoprotein enzymes which work together, and are necessary for normal tissue respiration. Also needed for activation of pyridoxine and conversion of tryptophan to niacin.
Therapeutic use
Prevention of riboflavin deficiency and treatment of ariboflavinosis.
Pregnancy and lactiation implications
Use with caution during pregnancy. Compatible with breast-feeding.
Unlabeled use
Contraindications
Warnings and precautions
Single vitamin deficiency is rare.