Salsalate
- Atc Codes:N02BA06
- CAS Codes:552-94-3
- PHARMGKB ID:552-94-3
Table of contents
- Brand Names
- Chemistry
- Pharmacologic Category
- Mechanism of Action
- Therapeutic Use
- Pregnancy and Lactation Implications
- Contraindications
- Warnings and Precautions
- Adverse Reactions
- Toxicological Effects
- Inhibits
- Drug Interactions
- Nutrition/Nutraceutical Interactions
- Dosage
- Pharmacokinetics and Pharmacodynamics
- Special Considerations
Brand Names
North America
USA: Disalcid, Salsalate.
Drug combinations
Chemistry
Salsalate: C~14~H~10~O~5~. Mw: 258.23. (1) Benzoic acid, 2-hydroxy-, 2-carboxyphenyl ester; (2) Disalicylic acid; (3) Salicylic acid, bimolecular ester. CAS-552-94-3 (1972).
Pharmacologic Category
Analgesics and Antipyretics; Nonsteroidal Anti-inflammatory Agents; Salicylates. (ATC-Code: N02BA06).
Mechanism of action
Weakly inhibits cyclooxygenase-1 (COX-1/PTGS1) and COX-2/PTGS2 enzymes, which results in decreased formation of prostaglandin precursors. Has antipyretic, analgesic, and anti-inflammatory properties. Does not inhibit platelet aggregation.
Therapeutic use
Minor pain or fever. Arthritis.
Pregnancy and lactiation implications
Avoid use in 3^rd^ trimester due to possible premature closure of ductus arteriosus. Enters breast milk (contraindicated in nursing women).
Unlabeled use
Contraindications
Known hypersensitivity to salsalate or any ingredient in the formulation. GI ulcer or bleeding. Pregnancy (3^rd^ trimester). History of asthma, urticaria, or other sensitivity reaction precipitated by aspirin or other NSAIDs. Perioperative pain in setting of coronary artery bypass graft surgery.
Warnings and precautions
Patients with sensitivity to tartrazine dyes, nasal polyps, and asthma may have increased risk of salicylate sensitivity. Previous nonreaction does not guarantee future safe taking of medication. Use with caution in platelet and bleeding disorders, in dehydration, in erosive gastritis or peptic ulcer, and in renal impairment. Children and teenagers who have or are recovering from chickenpox or flu-like symptoms should not use this product. Changes in behavior (along with nausea and vomiting) may be an early sign of Reye’s syndrome.