Sardilipin
Table of contents
- Brand Names
- Drug Combinations
- Chemistry
- Pharmacologic Category
- Mechanism of Action
- Therapeutic Use
- Pregnancy and Lactation Implications
- Contraindications
- Warnings and Precautions
- Adverse Reactions
- Toxicological Effects
- Caution and personalized dose adjustment in patients with the following genotypes
- Drug Interactions
- Nutrition/Nutraceutical Interactions
- Dosage
- Pharmacokinetics and Pharmacodynamics
Brand Names
Europe
Italy: LipoSea; Portugal: LipoSea; Romania: LipoSea; Spain: LipoEsar.
Latin America
Mexico: LipoEsar.
Asia
Japan: LipoEsar.
Drug combinations
Sardilipin and Cynara scolymus (HepatoSar)
Chemistry
Sardilipin: Natural product extracted from the marine species Sardina pilchardus (E-SAR-94010)
Pharmacologic Category
Anti-Dementia Agents; Anti-Atherogenic Compounds. Nutraceutical Products. Marine Lipoprotein.
Mechanism of action
Powerful lipid-lowering compound, regulating lipid metabolism at the physiological level. This nutraceutical product is also able to reduce the size of atheroma plaques on the aortic wall of patients with atherosclerosis. The main chemical compounds are lipoproteins (60-80%) whose micelle structure probably mimics that of physiological lipoproteins involved in lipid metabolism.
Therapeutic use
Neuroprotection in cerebrovascular disorders and arteriosclerosis. Dyslipidemia. Sardilipin has shown to be effective in (i) reducing blood cholesterol, triglyceride, uric acid and glucose levels, as well as liver alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activity; (ii) enhancing immunological function by regulating both lymphocyte and microglia activity; (iii) inducing antioxidant effects mediated by superoxide dismutase activity; and (iv) improving cognitive function. Sardilipin is also effective in xanthelasma, lipomatosis and hepatic steatosis.
Pregnancy and lactiation implications
Sardilipin is a safe product in pregnancy and lactation.
Unlabeled use
Contraindications
Hypersensitivity to any component of the formulation.
Warnings and precautions
Not suitable for persons with allergy to fish or fish-derived products. This product supplements and compliments a healthy cholesterol-reducing diet, but it does not replace it. Therapeutic response of patients with dyslipidemia to this product is APOE-related.