Table of contents

  • Brand Names
  • Chemistry
  • Pharmacologic Category
  • Mechanism of Action
  • Therapeutic Use
  • Pregnancy and Lactation Implications
  • Contraindications
  • Warnings and Precautions
  • Adverse Reactions
  • Drug Interactions
  • Genes that may be involved
  • Dosage
  • Pharmacokinetics and Pharmacodynamics
  • Special Considerations

Brand Names


Germany: Secrelux; Greece: Secrelux.

North America

USA: Chirhostim, Secreflo.

Drug combinations


Secretin: C~130~H~220~N~44~O~40~ (human). Mw: 3039.41; C~130~H~220~N~44~O~41~ (porcine). Mw: 3055.41. (human): (1) Secretin (porcine), 15-L-glutamic acid-16-glycine-; (2)L-Histidyl-L-seryl-L-α-aspartylglycyl-L-threonyl-L-phenylalanyl-L-threonyl-L-seryl-L-α-glutamyl-L-leucyl-L-seryl-L-arginyl-L-leucyl-L-arginyl-L-α-glutamylglycyl-L-alanyl-L-arginyl-L-leucyl-L-glutaminyl-L-arginyl-L-leucyl-L-leucyl-L-glutaminylglycyl-L-leucyl-L-valinamide.

(porcine): (1) Secretin (porcine): (2) L-Histidyl-L-seryl-L-α-aspartylglycyl-L-threonyl-L-phenylalanyl-L-threonyl-L-seryl-L-α-glutamyl-L-leucyl-L-seryl-L-arginyl-L-leucyl-L-arginyl-L-α-aspartyl-L-seryl-L-alanyl-L-arginyl-L-leucyl-L-glutaminyl-L-arginyl-L-leucyl-L-leucyl-L-glutaminylglycyl-L-leucyl-L-valinamide. CAS-108153-74-8 (human); CAS-17034-35-4 (porcine); CAS-1393-25-5 (2004).

Pharmacologic Category

Diagnostic Agents; Pancreatic Function. (ATC-Code: V04CK01).

Mechanism of action

Human and porcine secretin are both synthetically-derived products and are equally potent on osmolar basis. A hormone normally secreted by duodenal mucosa and upper jejunal mucosa. Increases volume and bicarbonate content of pancreatic juice. Stimulates flow of hepatic bile with high bicarbonate concentration. Stimulates gastrin release in Zollinger-Ellison syndrome.

Therapeutic use

Secretin-stimulation testing to aid in diagnosis of pancreatic exocrine dysfunction. Diagnosis of gastrinoma (Zollinger-Ellison syndrome). Facilitation of endoscopic retrograde cholangiopancreatography visualization.

Pregnancy and lactiation implications

Reproduction studies not conducted. Excretion in breast milk unknown (use caution).

Unlabeled use


Hypersensitivity to secretin or any component of the formulation. Acute pancreatitis.

Warnings and precautions

Potential for allergic reactions exists. Use with caution in hepatic impairment (including ethanol-induced disease; volume response to secretin may be exaggerated). Response may be blunted in presence of inflammatory bowel disease, anticholinergic agents, or following vagotomy (blunted response not indicative of pancreatic disease).



Legal Notice
Privacy Policy
Cookie Policy


Phone: +34-981-780505
Location: Sta Marta de, C. P. Babío, S/N, 15165 Bergondo, A Coruña

Copyright © 2023 WAGEM

Add to cart