Emergence agitation or delirium may occur. Postoperative hepatitis or hepatic dysfunction with or without jaundice reported. Use of other inhaled anesthetics associated with rare cases of perioperative hyperkalemia (higher risk in pediatric patients with underlying neuromuscular disease). Other abnormalities may include elevation in CPK and myoglobinuria. Arrhythmias may occur. May dilate cerebral vasculature and may, in certain conditions, increase intracranial pressure. May trigger malignant hyperthermia (avoid use in susceptible patients). Causes dose-dependent respiratory depression and blunted ventilatory response to hypoxia and hypercapnia. Hypoxic pulmonary vasoconstriction blunted, which may lead to increased pulmonary shunt. Use with caution in hepatic/renal impairment, and in risk for seizures (seizures reported in children and young adults). Reaction of sevoflurane with CO~2~ absorbents which become desiccated within circle breathing equipment can lead to formation of formaldehyde (causing respiratory irritation) and carbon monoxide.