Sodium Iodide 131I

Table of contents

  • Brand Names
  • Drug Combinations
  • Chemistry
  • Pharmacologic Category
  • Therapeutic Use
  • Pregnancy and Lactation Implications
  • Contraindications
  • Warnings and Precautions
  • Adverse Reactions
  • Caution and personalized dose adjustment in patients with the following genotypes
  • Other genes that may be involved
  • Drug Interactions
  • Dosage
  • Pharmacokinetics and Pharmacodynamics
  • Special Considerations

Brand Names


Austria: Capsion Iod-131, Curicap, Natriumjodid ^131^I, Theracap 131; Belgium: Iodure de Sodium; Bulgaria: Sodium Iodide ^131^I, Theracap 131tm; Estonia: Sodium Iodide ^131^I, Theracap 131tm; France: Capsion, Iodure ^131^I de Sodium; Germany: Capsion Natriumiodid ^131^I, Diagnostikkapseln ^131^I AB, Iodid ^131^I NAB, Natriumiodid ^131^I, Natriumjodid [131-J], Theracap131, Therapiekapseln ^131^I AB; Greece: Sodium iodide ^131^I; Ireland: Sodium Iodide ^131^I; Lithuania: JodiPol, Natrio jodidas ¹³¹I, Theracap 131; Malta: Sodium Iodide ¹³¹I Diagnostic; Netherlands: Capsion, Curicap, Joodtinctuur, Sodium Iodide ^131^I, Theracap 131; Poland: Jodek sodu Na-131 J; Portugal: Capsion, Curicap, I-131-S-1, I-131-S-2, Iodeto de Sódio ^131^I, Theracap; Romania: Iodura de Sodiu ^131^I, Radioiodura (^131^I) de Sodiu, Theracap 131, Thyrotop Pentru Terapie; Slovakia: ^131^I Sodium iodide, ^131^I Jodid Sodný, Theracap 131 ^TM^; Spain: Curicap, Ioduro ^131^I de Sodio; Sweden: Capsion, Natriumjodid (I-131), Theracap.

North America

Canada: Micro I, Sodium Iodide; USA: Hicon, Sodium Iodide ^131^I.


Japan: Radiocaps.

Drug combinations

Sodium Iodide and Calcium Chloride

Sodium Iodide and Potassium Iodide

Sodium Iodide, Ammonium Molybdate, Chromic Chloride, Cobalt Gluconate, Copper Gluconate, Iron Gluconate, Magnanese Gluconate, Sodium Fluoride, Sodium Selenite, and Zinc Gluconate


Sodium Iodide (^131^I): Na^131^I. CAS-7790-26-3 (1963).

Pharmacologic Category

Diagnostic Agents; Thyroid Function. Antithyroid Agent. Radiopharmaceutical. (ATC-Code: V09FX02; V09FX03; V10XA01).

Mechanism of action

Therapeutic use

Diagnostic use with radioactive iodide uptake test to evaluate thyroid function. Treatment of hyperthyroidism and select cases of thyroid cancer.

Pregnancy and lactiation implications

Iodine (^131^I) crosses placenta and may cause severe and irreversible hypothyroidism in neonates. Pregnancy should be ruled out prior to therapy. Enters breast milk (not recommended in nursing women).

Unlabeled use


Hypersensitivity to iodine or any component of the formulation. Pre-existing vomiting and diarrhea (treatment). Concurrent antithyroid medication. Pregnancy.

Warnings and precautions

Hyperthyroidism/thyrotoxic cardiac disease may be aggravated by radiation thyroiditis. Hypochloremia may increase thyroid uptake of sodium iodide (^131^I). Use with caution in renal impairment (risk of adverse reactions may be increased; nephrosis may increase thyroid uptake of sodium iodide (^131^I)). Concomitant use of iodine, thyroid, or antithyroid medications may interfere with uptake of radioiodide. Use not generally recommended for treatment of hyperthyroidism in patients <30 years of age. Some dosage forms may contain sodium bisulfite which may cause allergic reactions in some individuals.



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