Sodium Tetradecyl Sulfate
- Atc Codes:C05BB04
- CAS Codes:139-88-8#4754-44-3
- PHARMGKB ID:139-88-8#4754-44-3
Table of contents
- Brand Names
- Chemistry
- Pharmacologic Category
- Mechanism of Action
- Therapeutic Use
- Pregnancy and Lactation Implications
- Contraindications
- Warnings and Precautions
- Adverse Reactions
- Drug Interactions
- Dosage
- Special Considerations
Brand Names
Europe
France: Trombovar; Hungary: Fibro-Vein; Ireland: Fibro-Vein; Italy: Fibro-Vein, Trombovar; Malta: Fibro-Vein; Netherlands: Trombovar; Poland: Fibro Vein; Slovakia: Fibro-Vein; UK: Fibro-Vein.
North America
Canada: Tromboject; USA: Sotradecol.
Latin America
Argentina: Fibro-Vein.
Drug combinations
Chemistry
Sodium Tetradecyl Sulfate: C~14~H~29~NaO~4~S. Mw: 316.43. Sodium 7-ethyl-2-methyl-4-undecanol sulfate. CAS-139-88-8; CAS-4754-44-3 (1-tetradecanol hydrogen sulfate).
Pharmacologic Category
Cardiovascular Drugs; Sclerosing Agents. (ATC-Code: C05BB04).
Mechanism of action
Acts by irritation of vein intimal endothelium and causes thrombosis formation leading to occlusion of injected vein.
Therapeutic use
Small, uncomplicated varicose veins of lower extremities.
Pregnancy and lactiation implications
Reproduction studies not conducted. Excretion in breast milk unknown (use with caution in nursing women).
Unlabeled use
Contraindications
Hypersensitivity to sodium tetradecyl or any component of the formulation. Arterial disease, acute thrombophlebitis. Valvular or deep vein incompetence, phlebitis migrans, cellulitis, acute infections. Bedridden patients. Uncontrolled systemic disease such as diabetes, toxic hyperthyroidism, tuberculosis, asthma, neoplasm, sepsis, blood dyscrasias, and acute respiratory or skin diseases. Huge superficial veins with wide open communications to deeper veins. Allergic conditions. Varicosities caused by abdominal and pelvic tumors (unless tumor removed).
Warnings and precautions
Observe for hypersensitivity/anaphylactic reaction. Deep vein thrombosis and pulmonary embolism occurred following treatment. Use with caution in peripheral arteriosclerosis, and in thromboangiitis obliterans. Valvular and venous competency should be evaluated prior to use. Avoid extravasation.