Soybean Oil (I.V. Emulsion)

Table of contents

  • Brand Names
  • Drug Combinations
  • Chemistry
  • Pharmacologic Category
  • Mechanism of Action
  • Therapeutic Use
  • Pregnancy and Lactation Implications
  • Contraindications
  • Warnings and Precautions
  • Adverse Reactions
  • Genes that may be involved
  • Inhibits
  • Toxicological Effects
  • Drug Interactions
  • Dosage

Brand Names

Austria: Intralipid; Czech Republic: Intralipid, Soyacal; Denmark: Intralipid; Finland: Intralipid; France: Intralipide, Ivelip; Germany: Salvilipid, Soyacal; Greece: Intralipid; Hungary: Intralipid; Ireland: Intralipid; Italy: Intralipid; Luxembourg: Intralipid; Malta: Intralipid; Netherlands: Intralipid; Poland: Intralipid; Portugal: Intralipid; Romania: Intralipid; Slovakia: Intralipid; Spain: Intralipid, Soyacal; Sweden: Intralipid.

North America

Canada: Intralipid; USA: Intralipid, Liposyn III, Soyacal.

Latin America

Argentina: Soyacal.


Japan: Intrafat, Intralipid.

Drug combinations

Soybean Oil and Egg Phospholipids

Soybean Oil and Olive Oil

Soybean Oil and Safflower Oil

Soybean Oil, Egg Phospholipids, and Safflower Oil

Soybean Oil and Omega-3-Acid Triglycerides

Soybean Oil and Medium Chain Triglycerides

Other Soybean Oil combinations: Alanine; Aminoacetic Acid; Arginine; Aspartic Acid; Calcium Chloride; Calcium Glycerophosphate; Cysteine; Dextrose; Egg Lecithin; Garlic; Onion; Glutamic Acid; Glycerol; Hawthorn Fruit, Leaves and Flowers; Histidine; Isoleucine; Leucine; Lycine Acetate; L-Lysine; Magnesium; Methionine; Mistletoe Herb; Phenylalanine; Potassium; Proline; Serine; Sodium; Sodium Chloride; Sodium Glycerophosphate; Sodium Hydroxide; Sodium Oleate; Threonine; Tocopherol (Vitamin E); Tryptophan; Tyrosine; Valine; Zinc Acetate


Soybean Oil (Hydrogenated): CAS-8016-70-4.

Pharmacologic Category

Nutritional Supplements.

Mechanism of action

Particle size less than 1 micron; gives a stable emulsion and excludes risk of fat embolism. Soybean Oil Intralipid enters bloodstream in a similar manner to natural chylomicron-rich lymph in both size and form, and is eliminated from circulation according to the same kinetic principles as dietary chylomicron-rich lymph. Formulated as a concentrated source of energy to be used together with carbohydrates and amino acids in parenteral nutrition; it is isotonic, and provides a source of basal phosphate requirements and of vitamin E.

Therapeutic use

Preoperative and postoperative nutritional disturbances where improved nitrogen balance is required. Nutritional disorders or disturbances of nitrogen balance due to inadequate or failing intestinal absorption caused by tumors in gastrointestinal tract, acute or chronic intestinal diseases (peritonitis, ulcerative colitis, terminal ileitis). Burns, to reduce the frequently excessive nitrogen losses. Prolonged unconsciousness, e.g. following cranial trauma or poisoning in cases where enteral feeding is inappropriate or impossible. Impaired renal function where a concentrated source of energy may be indicated to reduce protein breakdown. Cachexia and patients with Essential Fatty Acid Deficiency who cannot maintain or restore a normal essential fatty acid pattern by oral intake.

Pregnancy and lactiation implications

Unknown whether soybean oil can cause fetal harm when administered to pregnant women or can affect reproductive capacity. Unknown whether soybean oil can enter maternal milk.

Unlabeled use


Contraindicated in impaired ability to metabolize fat, such as in severe liver damage and acute shock. Hypersensitivity to soya or to any of the active substances or excipients.

Warnings and precautions

Fat metabolism may be disturbed in conditions such as renal insufficiency, uncompensated diabetes, pancreatitis, certain forms of liver insufficiency, metabolic disorders and sepsis. If intravenous fat is considered to be indicated in the abovementioned disorders, elimination of fat should be checked daily. In cases of verified or suspected liver insufficiency, liver condition and function must be closely followed. Formulation contains soya oil and egg lecithin which may rarely cause allergic reactions. Cross-allergic reaction observed between soya-bean and peanut. Soybean oil should be given with caution to neonates and premature infants with hyperbilirubinemia and in cases with suspected pulmonary hypertension. In low birthweight infants, the risk of lipid infusions may outweigh potential benefits due to further diminution of defenses against infection. In infants, metabolism of lipids in peripheral tissues may be diminished by infection and heparin administration. In neonates receiving long-term parenteral nutrition, particularly premature neonates, platelet count, liver function tests and serum triglyceride concentration should be monitored. Soybean oil may interfere with certain laboratory measurements (bilirubin, lactate dehydrogenase, oxysaturation, hemoglobin), if blood is sampled before fat has been adequately cleared from the bloodstream. Fat is cleared after a fat-free interval of 5-6 hours in most patients.



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